Drug therapy: dose-response relationship of oral mesalazine in inflammatory bowel disease [PDF]
Mediators of Inflammation, 1998 Mesalazine is widely used in the treatment of inflammatory bowel disease. Little is known about the doseresponse relationship and about possible dose related side effects.
C. J. J. Mulder, S. J. Van Den Hazel
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Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]
BMC Medical Research Methodology, 2017 Background It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug being developed for the treatment of
Feng Liu +2 more
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A simple calculation of the maximum dose of the local anesthetic in pediatric dentistry with nomogram [PDF]
Vojnosanitetski Pregled, 2022 nema
Mladenović Raša
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Evaluating the relationship between Ex3 vNTR and rs3758653 polymorphisms in DRD4 genes in children with attention deficit hyperactivity disorder with respect to the dose of methylphenidate [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders starting at an early age with symptoms of attention deficit hyperactivity disorder and impulsivity.
Shahrokh Amiri +5 more
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Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag +6 more
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drexplorer: A tool to explore dose–response relationships and drug–drug interactions [PDF]
Bioinformatics, 2015 AbstractMotivation: Nonlinear dose–response models are primary tools for estimating the potency [e.g. half-maximum inhibitory concentration (IC) known as IC50] of anti-cancer drugs. We present drexplorer software, which enables biologists to evaluate replicate reproducibility, detect outlier data points, fit different models, select the best model ...
Lauren Averett Byers +8 more
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Frontiers in Pharmacology, 2021 Traditional methods to standardize exposures in pharmacoepidemiologic studies, like defined daily-doses, may be inadequate to capture drug class effects when there are many in-class medications, formulations, and administration routes.
Kaleen N. Hayes +8 more
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Histopathologic investigations of nifedipine-induced gingival hyperplasia in Wistar rats [PDF]
Vojnosanitetski Pregled, 2005 Background. Nifedipine, a calcium channel blocker, used in the therapy of cardiovascular diseases, can induce gingival overgrowth. The aim of the study was to assess the influence of nifedipine on the deeper periodontal tissues of the experimental ...
Brkić Zlata
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The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]
Vojnosanitetski Pregled, 2009 Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana +3 more
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Dose-Response Relationship between Antimicrobial Drugs and Livestock-Associated MRSA in Pig Farming1 [PDF]
Emerging Infectious Diseases, 2015 The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands.
Dorado-García, Alejandro +6 more
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