A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe [PDF]
Frontiers in Pharmacology, 2021 Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen +7 more
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Drug therapy: dose-response relationship of oral mesalazine in inflammatory bowel disease [PDF]
Mediators of Inflammation, 1998 Mesalazine is widely used in the treatment of inflammatory bowel disease. Little is known about the doseresponse relationship and about possible dose related side effects.
C. J. J. Mulder, S. J. Van Den Hazel
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Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery [PDF]
npj Precision OncologyDrug response prediction is hampered by uncertainty in the measures of response and selection of doses. In this study, we propose a probabilistic multi-output model to simultaneously predict all dose–responses and uncover their biomarkers.
Juan-José Giraldo Gutierrez +6 more
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Dose optimisation and scarce resource allocation: two sides of the same coin [PDF]
BMJ Open, 2022 Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and ...
Govind Persad +3 more
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Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]
BMC Medical Research Methodology, 2017 Background It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug being developed for the treatment of
Feng Liu +2 more
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Using machine learning to model dose–response relationships [PDF]
Journal of Evaluation In Clinical Practice, 2016 Rationale, aims and objectivesEstablishing the relationship between various doses of an exposure and a response variable is integral to many studies in health care.
Linden, Ariel +2 more
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Model-based meta-analysis of HbA1c reduction across SGLT2 inhibitors using dose adjusted by urinary glucose excretion [PDF]
Scientific ReportsThis study was aimed to evaluate whether the dose–response relationship of the sodium glucose co-transporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)—canagliflozin, dapagliflozin, empagliflozin, ipragliflozin ...
Hiromi Sato +5 more
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A simple calculation of the maximum dose of the local anesthetic in pediatric dentistry with nomogram [PDF]
Vojnosanitetski Pregled, 2022 nema
Mladenović Raša
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Evaluating the relationship between Ex3 vNTR and rs3758653 polymorphisms in DRD4 genes in children with attention deficit hyperactivity disorder with respect to the dose of methylphenidate [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders starting at an early age with symptoms of attention deficit hyperactivity disorder and impulsivity.
Shahrokh Amiri +5 more
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Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag +6 more
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