Results 21 to 30 of about 925,610 (310)
The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Tacrolimus concentration-dose ratio as a potential therapeutic drug monitoring strategy was suggested to be used for the patients subjected to renal transplantation.
Rančić Nemanja +7 more
doaj +1 more source
Chronic inducible urticaria: confirmation through challenge tests and response to treatment
Einstein (São Paulo), 2020 Objective To evaluate the positivity of challenge tests of patients suspected of chronic inducible urticaria and the response to treatment. Methods A retrospective study of electronic medical records of patients suspected of chronic inducible ...
Amanda Rocha Firmino Pereira +3 more
doaj +2 more sources
Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials. [PDF]
, 2020 BackgroundAs progress continues in oncology drug development, this study aimed to examine whether the previously established association between drug dose and efficacy in the era of cytotoxic therapies remains true in today's phase I dose-escalation ...
Chen, Emerson Y +4 more
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 Dose–response analysis is often applied to the quantification of drug‐effect especially for slowly responding disease end points where a comparison is made across dose levels after a particular period of treatment.
James W. T. Yates, Hitesh B. Mistry
doaj +1 more source
Medicina, 2023 Background and Objectives: The dose selection for isobaric bupivacaine determines the success of spinal anesthesia (SA). A dose higher than the optimal dose causes high SA, whereas an underdose leads to inadequate spread of cephalad.
Ornwara Visavakul +5 more
doaj +1 more source
Model Selection versus Model Averaging in Dose Finding Studies [PDF]
, 2015 Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn +3 more
core +2 more sources
Health Physics, 2019 Well-characterized animal models that mimic the human response to potentially lethal doses of radiation are required to assess the efficacy of medical countermeasures under the criteria of the US Food and Drug Administration’s Animal Rule. Development of
T. MacVittie +7 more
semanticscholar +1 more source
Understanding and applying pharmacometric modelling and simulation in clinical practice and research [PDF]
, 2016 Understanding the dose-concentration-effect relationship is a fundamental component of clinical pharmacology. Interpreting data arising from observations of this relationship requires the use of mathematical models; i.e.
Standing, JF
core +1 more source
Cancer Biology & Medicine, 2010 OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups: 0, 2, 5, 10, 17 ...
Ping WANG +3 more
doaj +1 more source
Journal of Managed Care & Specialty Pharmacy, 2016 BACKGROUND: Systemic corticosteroids are a leading cause of drug-related complications, yet little has been done to quantify the dose-response relationship between systemic corticosteroid exposure and complications in patients with severe asthma ...
Anand A. Dalal +9 more
semanticscholar +1 more source