Results 91 to 100 of about 11,727,114 (306)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Summary of Dose-Response Modeling for Developmental Toxicity Studies

, 2008
Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation.
Shesh N. Rai, Daniel L. Hunt, Chin-Shang Li   +2 more
core   +1 more source

Dose-response relationship between evening exercise and sleep

Nature Communications
Public health guidelines recommend exercise as a key lifestyle intervention for promoting and maintaining healthy sleep function and reducing disease risk. However, strenuous evening exercise may disrupt sleep due to heightened sympathetic arousal.
Josh Leota, David M. Presby, Flora Le, Mark É. Czeisler, Luis Mascaro, Emily R. Capodilupo, Joshua F. Wiley, Sean P. A. Drummond, Shantha M. W. Rajaratnam, Elise R. Facer-Childs   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Geometric construction of optimal designs for dose-responsemodels with two parameters [PDF]

In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a ...
Zhu, Wei, Dette, Holger, Biedermann, Stefanie   +2 more
core  

Dose-response relationship of selective serotonin reuptake inhibitor (SSRI) in the treatment of depression: Protocol for a systematic review of reviews and meta-synthesis [PDF]

, 2021
Background: Antidepressant prescribing continues to grow (1,2). In part this is due to the use and availability of SSRIs (3), increased long-term prescribing (4), and the use of higher doses (5-7).
Johnson, Christopher
core  

Pioglitazone and bladder cancer risk: a systematic review and meta‐analysis

Cancer Medicine, 2018
Current evidence about the association between pioglitazone and bladder cancer risk remains conflict. We aimed to assess the risk of bladder cancer associated with the use of pioglitazone and identify modifiers that affect the results.
Huilin Tang, Weilong Shi, Shuangshuang Fu, Tiansheng Wang, Suodi Zhai, Yiqing Song, Jiali Han   +6 more
doaj   +1 more source

Resposta imune humoral de cães à vacina inativada, de cérebro de camundongos lactentes, utilizada nas campanhas anti-rábicas no Brasil Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil

Revista de Saúde Pública, 1997
INTRODUÇÃO: A campanha anti-rábica no Brasil é realizada anualmente utilizando a vacina de cérebro de camundongos lactentes Fuenzalida-Palacios. A resposta imune humoral de cães vacinados durante as campanhas foi analisada objetivando avaliar se os cães ...
Marilene F. Almeida, Elizabeth A. C. Aguiar, Luzia A. F. Martorelli, Douglas Presotto, Marcelo M. Brandão, Octávio A. C. Pereira   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nonparametric Estimators of Dose-Response Functions [PDF]

We propose two semiparametric estimators of the dose-response function based on spline techniques. Under uncounfoundedness, the generalized propensity score can be used to estimate dose-response functions (DRF) and marginal treatment effect functions. In
MATTEI Alessandra, FLORES Carlos A., BIA Michela   +2 more
core