Results 81 to 90 of about 728,551 (263)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Population pharmacokinetics [PDF]

Vojnosanitetski Pregled, 2005
Milovanović Jasmina R., Janković Slobodan M.   +1 more
doaj   +1 more source

The association between birthweight and adult lung function: insights from the UK Biobank

BMC Pulmonary Medicine
Background The potential association between birthweight and adult lung function has been postulated, yet the precise nature of this association in later life remains inconclusive.
Yu Wang, Yuanyi Zhang, Yacong Bo, Pengfei Li, Tianci Jiang, Yue Li, Zhe Cheng, Yongjian Zhu   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Dose–Response Relationship Between Aircraft Noise Exposure and Community Annoyance: A Case Study of Hangzhou Xiaoshan International Airport

Noise and Health
Objective:With increasing air traffic, aircraft noise pollution near Hangzhou Xiaoshan International Airport has intensified, raising concerns about community annoyance.
Jiakang Lv, Yinuo Chen, Mengze Yang, Qihan Zeng, Qianqian Zhou, Jiabin Chen, Yong Liu   +6 more
doaj   +1 more source

Intracoronary Adenosine: Dose-Response Relationship With Hyperemia.

JACC. Cardiovascular interventions, 2015
The present study sought to establish the dosage of intracoronary (IC) adenosine associated with minimal side effects and above which no further increase in flow can be expected.Despite the widespread adoption of IC adenosine in clinical practice, no wide-ranging, dose-response study has been conducted.
Adjedj, Julien, Toth, Gabor G, Johnson, Nils P, PELLICANO, MARIANO, Ferrara, Angela, Floré, Vincent, Di Gioia, Giuseppe, BARBATO, EMANUELE, Muller, Olivier, De Bruyne, Bernard   +9 more
openaire   +3 more sources