Results 61 to 70 of about 1,331,644 (204)

Investigating A Dose Response Relationship between High Fat Diet Consumption and the Contractile Performance of Isolated Mouse Soleus, EDL and Diaphragm Muscles [PDF]

, 2019
PurposeRecent evidence has demonstrated an obesity-induced, skeletal muscle-specific reduction in contractile performance. The extent and magnitude of these changes in relation to total dose of high-fat diet consumption remains unclear.
A Abdelmoula, A Matsakas, A Wronska, BH Goodpaster, C Barclay, C Barclay, Cameron Hill, CJ Blimkie, CJ Tanner, D Akhmedov, D Pette, D Tomlinson, DM D’Souza, DS Ward, F Zurlo, FR Paolillo, H Eshima, J Aucouturier, J Ciapaite, J Kemp, J Machann, J Mendez, J Szymura, J Tallis, J Tallis, J Tallis, J Tallis, J Tallis, J Wilde de, Jason Tallis, JD Altringham, JD Bruton, Josh Hurst, KE Shortreed, KE Trajcevski, M Hulens, MA Brotto, MM Thomas, MS Denies, N Miyatake, NA Maffiuletti, NA Maffiuletti, P Capodaglio, P Kopelman, P Rogers, R Singh, RK Josephson, RK Josephson, Rob S. James, RS James, RS James, RS James, S Warmington, SR Anderson, Val M. Cox, Y Rolland, Y Yoshida   +56 more
core   +1 more source

Dose–Response Relationship Between BMI and Hyperuricemia

International Journal of General Medicine, 2021
Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection,
Yang L, He Z, Gu X, Cheng H, Li L
doaj  

Methotrexate Pharmacokinetics and Survival in Osteosarcomat [PDF]

, 2004
The aim of this study was to analyze the relationship between exposure to high-dose methotrexate (HDMTX) and tumor response in terms of survival in children with osteosarcoma.
Aldaz, A. (Azucena), Aquerreta, I. (Irene), Giraldez, J. (J.), Sierrasesumaga, L. (Luis)   +3 more
core   +1 more source

Dose-Response Relationship in Aminonucleoside Nephrosis.

Experimental Biology and Medicine, 1963
SummaryAdministration of 1–3 mg of PA subcutaneously to normal rats at intervals of 1–2 weeks produced significant proteinuria after a prolonged latent period provided the total dose exceeded a threshold dose of approximately 4–5 mg. Analysis of the cumulative dose-response curves revealed that doses administered subcutaneously at biweekly intervals ...
C S, ALEXANDER, V R, HUNT, H T, NAGASAWA
openaire   +2 more sources

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study. [PDF]

, 2017
BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type ...
Braiteh, F, Burris, H, Cohn, AL, Foster, P, Kelley, RK, Lee, Y, Spira, A, Su, W-C, Van Cutsem, E, Verslype, C, Vogelzang, N, Yang, T-S   +11 more
core  

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]

, 2017
BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials.
AE Raftery, EH Choy, EJ Calabrese, F Behrens, Feng Liu, J Arrowsmith, J Fransen, J Heydari, K Almstrup, M Hay, MK Smith, N Thomas, P Brain, SC Owen, Stephen J. Walters, Steven A. Julious, W Stohl, Z Skrivanek   +17 more
core   +2 more sources

Optimal exercise modalities and dose for enhancing intelligence in children and adolescents: a Bayesian network meta-analysis

Frontiers in Physiology
BackgroundTo compare the effects of various exercise modalities on intelligence and determine the optimal exercise dose for children and adolescents.MethodsA systematic review and Bayesian network meta-analysis following PRISMA guidelines was conducted ...
Yan Wang, Junyu Wang, Lin Zhang, Chengji Wang, Guotuan Wang, Guotuan Wang, Changdong Li, Yuan Yuan, Bopeng Qiu, Yong Yang   +9 more
doaj   +1 more source

Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules

, 2020
Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis.
Friede, Tim, Günhan, Burak Kürsad, Meyvisch, Paul   +2 more
core   +1 more source

The association of at-risk, problem, and pathological gambling with substance use, depression, and arrest history [PDF]

, 2010
We examined at-risk, problem, or pathological gambling co-occurrence with frequency of past-year alcohol, tobacco, and marijuana use; depressive symptoms; and arrest history.
Delva, Jorge, Grogan-Kaylor, Andrew, Momper, Sandra L., Sanchez, Ninive, Volberg, Rachel A.   +4 more
core   +1 more source

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers

Thoracic Cancer, 2023
Background Betel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties.
Chih‐Lang Lin, Wan‐Ming Chen, Ben‐Chang Shia, Szu‐Yuan Wu   +3 more
doaj   +1 more source