Results 41 to 50 of about 1,351,500 (304)

Preclinical Evaluation of Botulinum Toxin Type E (TrenibotulinumtoxinE) Using the Mouse Digit Abduction Score (DAS) Assay

Toxins
TrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson, David Canty, Annemarie Southern, Kevin Whelan, Amy D. Brideau-Andersen, Ron S. Broide   +5 more
doaj   +1 more source

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag, Mikić Dragan, Arsić-Komljenović Gordana, Stanković Nebojša, Ristanović Elizabeta, Sjeničić Goran, Janićijević-Hudomal Snežana   +6 more
doaj   +1 more source

Model Selection versus Model Averaging in Dose Finding Studies [PDF]

, 2015
Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn, Bretz, Frank, Dette, Holger, Schorning, Kirsten   +3 more
core   +2 more sources

Analysis of the Dose-Response Effects of Physical Activity on Cardiocerebrovascular and All-Cause Mortality in Hypertension

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeisure-time moderate-to-vigorous physical activity (MV-PA) has been consistently regarded as a protective factor to prevent and treat hypertension.
Jun-Peng Xu, Jun-Peng Xu, Rui-Xiang Zeng, Rui-Xiang Zeng, Hai-Ning Lu, Yu-Zhuo Zhang, Yu-Zhuo Zhang, Xiao-Yi Mai, Xiao-Yi Mai, Shuai Mao, Shuai Mao, Min-Zhou Zhang, Min-Zhou Zhang   +12 more
doaj   +1 more source

Influence of Multiple Traumatic Event Types on Mental Health Outcomes: Does Count Matter? [PDF]

, 2018
The experience of potentially traumatizing events (PTEs) may be associated with conflicting outcomes: individuals may experience greater psychological distress (dose-response theory), or individuals may become more resilient against repeated PTEs (stress-
Brown, Lily A, Contractor, Ateka A, Dranger, Paula, Frankfurt, Sheila B, Gerber, Monica M, Oudshoorn, Kelsey   +5 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis

BMC Nephrology
Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis
Ye Yao, Jing Xiong, Mi-Yuan Wang
doaj   +1 more source

The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials

Complementary Therapies in Medicine
Objective: To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing ...
Guodong Li, Xinyu Hu, Jingli Xing, Yiying Wang, Chenlu Wang, Wennan Yu, Jie Lian, Huijuan Cao   +7 more
doaj   +1 more source

Effects of Aerobic and Speed Training Versus Active Control on Repeated Sprint Ability and Measures of Self-confidence and Anxiety in Highly Trained Male Soccer Players

Sports Medicine - Open, 2023
Background While there is ample evidence on the effects of single-mode aerobic and speed training on physical fitness in soccer players, less is known on the combined effects of these exercise regimens on physical and psychological factors.
Walid Selmi, Raouf Hammami, Sofien Kasmi, Sonia Sehli, Haithem Rebai, Michael Duncan, Mokhtar Chtara, Urs Granacher   +7 more
doaj   +1 more source