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Dose-response relationship

Abstract The dose-response relationship is the measurement of the relationship between the dose of a substance administered and its overall effect, the response. Knowledge of the dose-response is a key aspect of a medicine development programme and concepts such as the dose-response curve, effective dose (ED), toxic dose (TD) and ...
Phil Ambery, Adrian Kilcoyne, Daniel O’Connor   +2 more
  +4 more sources

Preclinical Evaluation of Botulinum Toxin Type E (TrenibotulinumtoxinE) Using the Mouse Digit Abduction Score (DAS) Assay

Toxins
TrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson, David Canty, Annemarie Southern, Kevin Whelan, Amy D. Brideau-Andersen, Ron S. Broide   +5 more
doaj   +1 more source

The H-ARS Dose Response Relationship (DRR): Validation and Variables [PDF]

, 2015
Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality.
Chua, Hui Lin, Feng, Hailin, Fisher, Alexa, Jackson, William, MacVittie, Thomas J., Orschell, Christie M., Plett, P. Artur, Sampson, Carol H., Sellamuthu, Rajendran, Vemula, Sasidhar, Wu, Tong   +10 more
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Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag, Mikić Dragan, Arsić-Komljenović Gordana, Stanković Nebojša, Ristanović Elizabeta, Sjeničić Goran, Janićijević-Hudomal Snežana   +6 more
doaj   +1 more source

Analysis of the Dose-Response Effects of Physical Activity on Cardiocerebrovascular and All-Cause Mortality in Hypertension

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeisure-time moderate-to-vigorous physical activity (MV-PA) has been consistently regarded as a protective factor to prevent and treat hypertension.
Jun-Peng Xu, Jun-Peng Xu, Rui-Xiang Zeng, Rui-Xiang Zeng, Hai-Ning Lu, Yu-Zhuo Zhang, Yu-Zhuo Zhang, Xiao-Yi Mai, Xiao-Yi Mai, Shuai Mao, Shuai Mao, Min-Zhou Zhang, Min-Zhou Zhang   +12 more
doaj   +1 more source

Influence of Multiple Traumatic Event Types on Mental Health Outcomes: Does Count Matter? [PDF]

, 2018
The experience of potentially traumatizing events (PTEs) may be associated with conflicting outcomes: individuals may experience greater psychological distress (dose-response theory), or individuals may become more resilient against repeated PTEs (stress-
Brown, Lily A, Contractor, Ateka A, Dranger, Paula, Frankfurt, Sheila B, Gerber, Monica M, Oudshoorn, Kelsey   +5 more
core   +1 more source

Design methods for some dose-response models [PDF]

, 1990
A recently described design method for one-parameter biomedical models such as limiting or serial dilution assays is generalized to two-parameter models for which the dose-response relationship can be expressed as a linear regression model with ...
Albers, Willem, Does, Ronald J.M.M., Strijbosch, Leo W.G.   +2 more
core   +2 more sources

Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis

BMC Nephrology
Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis
Ye Yao, Jing Xiong, Mi-Yuan Wang
doaj   +1 more source

The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials

Complementary Therapies in Medicine
Objective: To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing ...
Guodong Li, Xinyu Hu, Jingli Xing, Yiying Wang, Chenlu Wang, Wennan Yu, Jie Lian, Huijuan Cao   +7 more
doaj   +1 more source