Results 11 to 20 of about 748,662 (261)
World Allergy Organization Journal, 2020 Background: Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported.
Kiyotake Ogura +20 more
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Dose response relationship in anti-stress gene regulatory networks. [PDF]
PLoS Computational Biology, 2007 To maintain a stable intracellular environment, cells utilize complex and specialized defense systems against a variety of external perturbations, such as electrophilic stress, heat shock, and hypoxia, etc.
Qiang Zhang, Melvin E Andersen
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Evaluation of mutagenicity of zinc oxide nanoparticles by Pig-a mutation assay in vivo
Shanghai yufang yixue, 2022 ObjectiveThe genotoxicity of zinc oxide nanoparticles （ZnO NPs） in rats was determined by Pig⁃a mutation assay in vivo.MethodsCombined with 28-day oral toxicity test， male SD rats were given ZnO NPs by oral administration for 28 days， at doses of 0， 14 ...
CHENG Xueqing +4 more
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Modeling of dose-response relationships. [PDF]
Environmental Health Perspectives, 1981 The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it
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Dose-response relationship for breast cancer induction at radiotherapy dose
Radiation Oncology, 2011 Purpose Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer.
Gruber Günther +5 more
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Química Nova, 2008 Aquatic toxicity tests are assays performed with different aquatic organisms of different ecological organization levels. Such tests are a source of information on the toxicity of a given substance or wastewater under controlled conditions, and they ...
Carla Regina Costa +3 more
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Histopathologic investigations of nifedipine-induced gingival hyperplasia in Wistar rats [PDF]
Vojnosanitetski Pregled, 2005 Background. Nifedipine, a calcium channel blocker, used in the therapy of cardiovascular diseases, can induce gingival overgrowth. The aim of the study was to assess the influence of nifedipine on the deeper periodontal tissues of the experimental ...
Brkić Zlata
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The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]
Vojnosanitetski Pregled, 2009 Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana +3 more
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Cancer Biology & Medicine, 2010 OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups: 0, 2, 5, 10, 17 ...
Ping WANG +3 more
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ToxinsTrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson +5 more
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