Results 1 to 10 of about 227,184 (215)

Dose Optimization of Colistin: A Systematic Review

Antibiotics, 2021
Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-negative infections. We aimed to assess the available data on the dosing strategy of colistin.
Abdul Haseeb, Hani Saleh Faidah, Saleh Alghamdi, Amal F. Alotaibi, Mahmoud Essam Elrggal, Ahmad Jamal Mahrous, Safa S. Almarzoky Abuhussain, Najla A. Obaid, Manal Algethamy, Abdullmoin AlQarni, Asim A. Khogeer, Zikria Saleem, Aziz Sheikh   +12 more
doaj   +3 more sources

Dose optimization of remimazolam as an adjunct to propofol for gastroscopy sedation: a randomized double-blind trial [PDF]

Frontiers in Pharmacology
IntroductionPropofol-based sedation for gastroscopy is effective but may cause dose-dependent cardiorespiratory depression; therefore, optimizing adjunct strategies to reduce propofol exposure is clinically important.MethodsWe conducted a prospective ...
Yijie Zhang, Yijie Zhang, Shanshan Xia, Hai Wang, Hanbing Shen, Lian Fang, Yating Chen, Yuanyuan Pan, Nana Bao, Lili Yang, Yingchao Ye, Junlu Wang, Yunchang Mo, Yunchang Mo   +13 more
doaj   +2 more sources

Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model

Antibiotics, 2021
Enrofloxacin is frequently administered via drinking water for the treatment of colibacillosis in broiler chickens. However, the EMA/CVMP has urged to re-evaluate historically approved doses, especially for antimicrobials administered via drinking water.
Robin Temmerman, Ludovic Pelligand, Wim Schelstraete, Gunther Antonissen, An Garmyn, Mathias Devreese   +5 more
doaj   +3 more sources

Dose Optimization of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia [PDF]

Clinical Pharmacology: Advances and Applications
Jiali Chen,1,2 Yidan Zhu,1,3 Yinyu Zhao,1,3 Nan Guo,1,2 Yuxuan Yao,1,2 Xingxian Luo,1 Lin Huang1 1Department of Pharmacy, Peking University People’s Hospital, Beijing, People’s Republic of China; 2School of Life Science and Biopharmaceutics, Shenyang ...
Chen J, Zhu Y, Zhao Y, Guo N, Yao Y, Luo X, Huang L   +6 more
doaj   +2 more sources

Strategies for clinical dose optimization of T cell-engaging therapies in oncology

mAbs, 2023
Innovative approaches in the design of T cell-engaging (TCE) molecules are ushering in a new wave of promising immunotherapies for the treatment of cancer.
Kathryn Ball, Simon J Dovedi, Pavan Vajjah, Alex Phipps   +3 more
doaj   +1 more source

Inoculum-Based Dosing: A Novel Concept for Combining Time with Concentration-Dependent Antibiotics to Optimize Clinical and Microbiological Outcomes in Severe Gram Negative Sepsis

Antibiotics, 2023
Certain classes of antibiotics show “concentration dependent” antimicrobial activity; higher concentrations result in increased bacterial killing rates, in contrast to “time dependent antibiotics”, which show antimicrobial activity that depends on the ...
Alwin Tilanus, George Drusano
doaj   +1 more source

Modeling and Simulation to Support Phase Ib/IIa Dose Selection for WBP216, A Long Half-Life Fully Human Monoclonal Antibody Against Interleukin-6

Frontiers in Pharmacology, 2021
WBP216 is an innovative IL-6 antibody, presenting high affinity to IL-6 and a long half-life (40–60 days). To optimize the dosage regimen for future clinical trials, pharmacokinetics (PK) and pharmacodynamics (PD) of WBP216 would be firstly characterized
Xiange Tang, Xiange Tang, Xiaofeng Zeng, Xiaoduo Guan, Xiaoduo Guan, Rui Chen, Rui Chen, Pei Hu, Pei Hu   +8 more
doaj   +1 more source

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Cancer Reports, 2022
Background Children with febrile neutropenia commonly exhibit alterations of pharmacokinetic (PK) parameters, leading to decreased β‐lactam concentrations.
Sabine F. Maarbjerg, Anders Thorsted, Lena E. Friberg, Elisabet I. Nielsen, Mikala Wang, Henrik Schrøder, Birgitte K. Albertsen   +6 more
doaj   +1 more source

Pelvis imaging: Achieving dose reduction with different patient positions [PDF]

Nuclear Technology and Radiation Protection, 2019
The purpose of this research was to determine how dose area product, effective dose, absorbed doses to specific organs, and image quality changed according to different automatic exposure control positions in pelvis imaging.
Resnik Anja, Žibert Janez, Mekiš Nejc
doaj   +1 more source

Long-Term Dose Optimization of Adalimumab via Dose Spacing in Patients with Psoriasis

Bioengineering, 2022
Dose spacing (DS) can be useful for optimizing treatment with biologics in psoriasis patients. However, interval prolongation might increase the production of anti-drug antibodies (ADA) and, therefore, reduce the drug’s effectiveness.
Michael Benzaquen, Mohammad Munshi, Simon Bossart, Laurence Feldmeyer, Vladimir Emelianov, Nikhil Yawalkar, Simone Cazzaniga, Kristine Heidemeyer   +7 more
doaj   +1 more source