Results 21 to 30 of about 3,118,083 (256)

Software- and TDM-Guided Dosing of Meropenem Promises High Rates of Target Attainment in Critically Ill Patients

Antibiotics, 2023
Various studies have reported insufficient beta-lactam concentrations in critically ill patients. The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic patients, is an ongoing matter of discussion.
Ute Chiriac, Daniel Richter, Otto R. Frey, Anka C. Röhr, Sophia Helbig, Stefan Hagel, Uwe Liebchen, Markus A. Weigand, Alexander Brinkmann   +8 more
doaj   +1 more source

Balance Problems for Integer Circuits [PDF]

, 2018
We investigate the computational complexity of balance problems for {-,*}-circuits computing finite sets of natural numbers. These problems naturally build on problems for integer expressions and integer circuits studied by Stockmeyer and Meyer (1973 ...
Dose, Titus, Titus Dose
core   +1 more source

Dose Optimization of Vancomycin for Critically Ill Patients Undergoing CVVH: A Prospective Population PK/PD Analysis

Antibiotics, 2021
The optimal dose of vancomycin in critically ill patients receiving continuous venovenous hemofiltration (CVVH) remains unclear. The objective of this study was to identify factors that significantly affect pharmacokinetic profiles and to further ...
Chuhui Wang, Chao Zhang, Xiaoxiao Li, Sixuan Zhao, Na He, Suodi Zhai, Qinggang Ge   +6 more
doaj   +1 more source

Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Frontiers in Pharmacology, 2021
Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also exhibits different pharmacokinetic characteristics between adults and children.
Yahui Zhang, Yahui Zhang, Sixuan Zhao, Chuhui Wang, Chuhui Wang, Pengxiang Zhou, Suodi Zhai, Suodi Zhai   +7 more
doaj   +1 more source

ON THE AUTOMORPHISMS OF THE NONSPLIT CARTAN MODULAR CURVES OF PRIME LEVEL [PDF]

, 2016
We study the automorphisms of the nonsplit Cartan modular curves Xns(p) of prime level p. We prove that if p ≥ 29 all the automorphisms preserve the cusps.
VALERIO DOSE, Dose V.
core   +1 more source

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function

Infection and Drug Resistance, 2022
Matthias Gijsen,1,2 Omar Elkayal,1 Pieter Annaert,1,3 Ruth Van Daele,1,2 Philippe Meersseman,4 Yves Debaveye,4 Joost Wauters,4 Erwin Dreesen,1 Isabel Spriet1,2 1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium ...
Gijsen M, Elkayal O, Annaert P, Van Daele R, Meersseman P, Debaveye Y, Wauters J, Dreesen E, Spriet I   +8 more
doaj  

Investigating the dose- and sex-specific impacts of fenugreek (trigonella foenum-graecum) extract on liver enzymes and histology in male and female rats [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The liver is a vital organ susceptible to damage from various stressors, necessitating exploration of protective agents. Fenugreek (Trigonella foenum-graecum), known for its bioactive compounds, has shown potential hepatoprotective effects.
A.A. Ammari, A.R. Alhimaidi, R.A. Amran, H. Aljawdah, A.M. Rady   +4 more
doaj   +1 more source

Serdexmethylphenidate/dexmethylphenidate for children with attention-deficit/hyperactivity disorder: dose optimization from a laboratory classroom study

Frontiers in Psychiatry
ObjectiveTo evaluate treatment responder rate using the Attention-Deficit/Hyperactivity Disorder Rating Scale-5 (ADHD-RS-5) score based on optimized dose level of serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) and changes in ADHD severity in ...
Andrew J. Cutler, Andrew J. Cutler, Scott H. Kollins, Scott H. Kollins, Matthew N. Brams, Meg Corliss, Charles Oh, Rene Braeckman, Ann C. Childress   +8 more
doaj   +1 more source

A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints . [PDF]

, 2007
Bayesian decision procedures have already been proposed for and implemented in phase I dose-escalation studies in healthy volunteers. The procedures have been based on pharmacokinetic responses reflecting the concentration of the drug in blood plasma and
Hampson, Lisa, Pereira, Alvaro, Ledent, Edouard, Whitehead, John, Zhou, Yinghui   +4 more
core   +5 more sources

Dose calculations for [¹³¹I] meta-iodobenzylguanidine-induced bystander effects

, 2014
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment ...
R. J. Mairs, Seymour, C B, M. D. Gow, Mairs, R J, C. B. Seymour, Gow, M.D., Mothersill, C.E., Seymour, C.B., C. E. Mothersill, Mairs, R.J., M. Boyd, W. V. Prestiwch, Mothersill, C E, Prestiwch, W V, Prestiwch, W.V., Boyd, Marie, Boyd, M., Gow, M D   +17 more
core   +1 more source