Results 51 to 60 of about 3,118,083 (256)

OEDIPE, a software for personalized Monte Carlo dosimetry and treatment planning optimization in nuclear medicine: absorbed dose and biologically effective dose considerations

, 2014
For targeted radionuclide therapies, treatment planning usually consists of the administration of standard activities without accounting for the patient-specific activity distribution, pharmacokinetics and dosimetry to organs at risk.
A. Desbrée, C. de Labriolle Vaylet, A. Petitguillaume, D. Franck, M. Bernardini, Desbreé, A., Bernardini, M., Franck, D., D. Broggio, Broggio, D., Petitguillaume, A., de Labriolle Vaylet, C.   +11 more
core   +1 more source

Dosing Regimen Optimization of Aztreonam/Avibactam According to Renal Function Stratification: A Population Pharmacokinetic-Guided Simulation Study

Antibiotics
Background/Objectives: Aztreonam/avibactam is a promising treatment option for serious infections caused by metallo-β-lactamase-producing carbapenem-resistant Enterobacterales (MBL-CRE).
Ping Yang, Xianhua Zhang, Yufei Chen, Congya Zhou, Suodi Zhai   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From Anatomical to Clinical DRLs: Establishing Indication-Based CT Dose Benchmarks in Saudi Arabia

Diagnostics
Background: Although diagnostic reference levels (DRLs) based on anatomical regions are widely used in computed tomography (CT) imaging, a clinical-indication-based approach provides a more accurate representation of daily practice and protocol variation.
Abir Bouaoun, Reem M. Althubaiti, Rudinah W. Edreess, Afnan A. Malaih   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enhancing Anesthetic Precision Through Ejection Fraction- and Temperature-Informed Modeling

IEEE Access
The majority of anesthesia dosing remains population-based, often ignoring individual patients’ physiology, which can lead to under- or overdosing.
Yara Tulbah, Ibrahim Aljamaan
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Thermomechanical engineering of water-cooled plasma-facing components in fusion reactors

, 2021
Nuclear fusion is the reaction that fuels our Sun an the other stars. Adopting fusion on Earth as an energy source for electricity production offers unique advantages, such as: virtually unlimited and widely available fuel, intrinsic safety (no chain ...
DOSE, GIACOMO
core   +1 more source

Population pharmacokinetics and dose optimization of ceftazidime in critically ill children

Frontiers in Pharmacology
ObjectiveThe aim of this study was to develop a population pharmacokinetic model for ceftazidime in critically ill children in the pediatric intensive care unit (PICU) and optimize an appropriate dosing regimen for this population.MethodsWe performed a ...
Mengting Li, Liuliu Gao, Zuo Wang, Lingkong Zeng, Chen Chen, Jun Wang, Sichan Li, Maochang Liu, Yang Wang   +8 more
doaj   +1 more source