Results 61 to 70 of about 3,118,083 (256)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Optimizing the fluorescent visualization with Indocyanine green during laparoscopic cholecystectomy

Клиническая практика
BACKGROUND: The prevention of damaging the bile ducts during surgical interventions in patients with calculous cholecystitis remains a topical problem in modern abdominal surgery. The incidence of damaging the bile ducts reaches 0.4–2%, while in cases of
Mikhail V. Kosachenko, Alexander M. Leonovich, Aleksei E. Klimov, Anna V. Burlakova   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Short Course on Optimization Technology and Applications in High Frequency and Microwave Circuit Design

, 1994
Course notes and advertisement for a Short Course given at the Department of Electromagnetic Theory and Engineering, Duisburg University, Duisburg, Germany. The course was delivered by John W. Bandler and S.H. Chen on October 4 and 5, 1994.
Bandler, John W., Chen, S.H., Optimization Systems Associates   +2 more
core   +1 more source

Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model

Frontiers in Immunology
BackgroundTrough concentration of Infliximab (IFX) was associated with its efficacy and toxicity. However, traditional therapeutic drug monitoring often results in suboptimal outcomes because dose adjustments are delayed. We aimed to develop and validate
Yuewen Chen, Yuewen Chen, Shoutian Zhang, Shoutian Zhang, Si Chen, Shaojun Jiang, Shaojun Jiang, Shuifang Zhou, Shuifang Zhou, Jing Liu, Jing Liu, Zhoujie Liu, Zhoujie Liu, Rongfang Lin, Rongfang Lin, Jianwen Xu, Jianwen Xu   +16 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity

, 2017
Michael Huss,1 Praveen Duhan,2 Preetam Gandhi,3 Chien-Wei Chen,4 Carsten Spannhuth,3 Vinod Kumar5 1Child and Adolescent Psychiatry, University Medicine, Mainz, Germany; 2Global Medical Affairs, Novartis Healthcare Pvt.
Duhan P, Kumar V, Gandhi P, Huss M, Spannhuth CW, Chen CW   +5 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Internal dosimetry of non-uniform activity distributions: a simple method for the calculation of the absorbed dose distribution at voxel level in radionuclide therapy [PDF]

, 2013
Internal dosimetry of non-uniform activity distributions: a simple method for the calculation of the absorbed dose distribution at voxel level in radionulcide therapy Radiotherapy is the medical use of ionizing radiations to control or kill clonogenic ...
AVIGO, CINZIA
core  

Model-Informed Dose Optimization of Spironolactone in Neonates and Infants

Pharmaceuticals
Background/Objectives: Spironolactone (SP) has been used off-label in pediatrics since its approval, but its use is challenged by limited pharmacokinetic (PK) data in adults and especially in children. Methods: Physiologically based pharmacokinetic (PBPK)
Amira Soliman, Leandro F. Pippa, Jana Lass, Stephanie Leroux, Valvanera Vozmediano, Natalia V. de Moraes   +5 more
doaj   +1 more source