Results 31 to 40 of about 34,802 (246)

The effect of dose expectancies on caffeine withdrawal symptoms during tapered dose reduction

Journal of Psychopharmacology, 2018
Background: Negative expectancies can exacerbate withdrawal symptoms via the nocebo effect. As such, information provided about dose reductions during attempts to taper a drug could contribute to withdrawal symptoms and increase the likelihood of relapse. The current study tested whether blinding participants to
Llewellyn Mills, Robert A Boakes, Ben Colagiuri   +2 more
openaire   +5 more sources

Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

PLoS ONE, 2020
ObjectiveRecent guideline updates have suggested de-escalating DMARDs when patients with rheumatoid arthritis achieve remission or low disease activity. We aim to evaluate whether it is cost-effective to de-escalate the biological form of DMARDs (bDMARDs)
Benjamin Birkner, Jürgen Rech, Tom Stargardt   +2 more
doaj   +1 more source

How Do We Taper and Discontinue Opioids in Cancer Patients? Considerations from the Activities of a Palliative Care Team at a University Hospital

Palliative Medicine Reports, 2021
Background: The more the cancer treatments progress, the more the needs increase to taper and discontinue opioids in cancer patients. Furthermore, opioid dependence of cancer survivors has become a bigger problem.
Ayumi Kihara, Kazuki Shimada, Satoru Tsuneto   +2 more
doaj   +1 more source

Is Nonconsensual Tapering of High-Dose Opioid Therapy Justifiable? [PDF]

AMA Journal of Ethics, 2020
This case considers a so-called legacy patient, one whose behaviors and symptoms express a legacy of past, aggressive opioid prescribing by a clinician. Some prescribers might feel pressured to taper doses of opioids for such patients, but this article argues that nonconsensual dose reductions for stable opioid therapy patients is impermissible because
openaire   +2 more sources

Drug utilization of biological drugs in the treatment of chronic Immune-Mediated Inflammatory Diseases (IMIDs): an observational study on Italian patients

Global & Regional Health Technology Assessment, 2017
Drug utilization of biological drugs in the treatment of chronic Immune-Mediated Inflammatory Diseases (IMIDs): an observational study on Italian patientsObjectives:The aim of this analysis was to provide an estimate of drug utilization indicators (dose ...
Paolo Faccendini, Enrica Cantillo, Caterina Fanizza, Maria Grazia Celeste   +3 more
doaj   +1 more source

Tapering of biological antirheumatic drugs in rheumatoid arthritis patients is achievable and cost-effective in daily clinical practice: data from the Brussels UCLouvain RA Cohort

Arthritis Research & Therapy, 2020
Background/purpose Studies have demonstrated that rheumatoid arthritis (RA) patients who achieve low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs).
Stéphanie Dierckx, Tatiana Sokolova, Bernard R. Lauwerys, Aleksandra Avramovska, Laurent Meric de Bellefon, Adrien Nzeusseu Toukap, Maria Stoenoiu, Frédéric A. Houssiau, Patrick Durez   +8 more
doaj   +1 more source

Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study

RMD Open, 2022
Objective A subanalysis of the multicentre Early Lupus inception cohort was performed to investigate the real-world Glucocorticoids (GCs) Use in newly diagnosed systemic lupus erythematosus (SLE) Patients (GULP).Methods Patients starting prednisone (PDN)
Carlo Alberto Scirè, Alessandra Bortoluzzi, Fabrizio Conti, Andrea Doria, Micaela Fredi, Marcello Govoni, Chiara Tani, Marta Mosca, Alberto Cauli, Matteo Piga, Alberto Floris, Florenzo Iannone, Luca Iaccarino, Greta Carrara, Franco Franceschini, Anna Zanetti, Francesca Romana Spinelli, Francesca Bellisai, Roberto D'Alessandro, Elisabetta Chessa, Gian Domenico Sebastiani, Immacolata Prevete, Laura Coladonato   +22 more
doaj   +1 more source

Flare during tapering of biological DMARDs in patients with rheumatoid arthritis in routine care: characteristics and predictors

RMD Open, 2022
Objective To identify predictors of flare in a 2-year follow-up study of patients with rheumatoid arthritis (RA) in sustained clinical remission tapering towards withdrawal of biological disease-modifying anti-rheumatic drugs (bDMARDs).Methods Sustained ...
Merete Lund Hetland, Søren Jacobsen, Natalia Manilo, Niels Steen Krogh, Mikkel Østergaard, Karen Ellegaard, Mikael Boesen, L Terslev, Cecilie Heegaard Brahe, Simon Krabbe, Daniel Glinatsi, Stylianos Georgiadis, Dorte V Jensen, Annette Hansen, Viktoria Fana, Lars Juul, Karsten Asmussen, Henrik Røgind, L M Ørnbjerg, UM Dohn, Torsten Møller, Tuan Khai Huynh, Jesper Nørregaard, Zoreh Rastiemadabadi, Lone Morsel-Carlsen, Jakob Møllenbach Møller   +25 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Unsupervised machine learning identifies opioid taper reversal patterns in a longitudinal cohort (2008-2018).

PLOS Digital Health
Chronic pain is commonly treated with long-term opioid therapy, but rapid opioid dose tapering has been associated with increased adverse events. Little is known about heterogeneity in the population of patients on high dose opioids and their response to
Monika Ray, Joshua J Fenton, Patrick S Romano   +2 more
doaj   +1 more source