Results 51 to 60 of about 1,052,978 (300)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Efficient and regioselective synthesis of dihydroxy-substituted 2-aminocyclooctane-1-carboxylic acid and its bicyclic derivatives

Beilstein Journal of Organic Chemistry, 2022
The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is ...
İlknur Polat, Selçuk Eşsiz, Uğur Bozkaya, Emine Salamci   +3 more
doaj   +1 more source

Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance [PDF]

, 2012
Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components
A MacLeod, A Tait, Adalgisa Caccone, B Vanhollebeke, B Vanhollebeke, D Mehlitz, Daniel K. Masiga, DR Maddison, E Pays, EC Agbo, G Simo, HV Xong, JF Flot, Jon S. Beadell, Kehinde Agbebakun, L Vanhamme, M Clement, M Higgins, M Koffi, M Stephens, Mark Sistrom, O Balmer, Oliver Balmer, P Capewell, R Kieft, Rebecca E. Symula, RJ Wheeler, Serap Aksoy, SL Hajduk, W Gibson, WC Gibson, Wendy Gibson   +31 more
core   +3 more sources

Homonuclear Internuclear Double Resonance Spectroscopy as a Basis for Determination of Amino Acid Conformation [PDF]

Proceedings of the National Academy of Sciences, 1972
INDOR (Internuclear Double Resonance) spectroscopy is shown to be superior to conventional (spectra obtained not by sweeping , but by maintaining constant the decoupling frequency) nuclear single- or double-resonance techniques for conformational studies of amino acids and amino acid residues
W A, Gibbons, H, Alms, J, Sogn, H R, Wyssbrod   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium. [PDF]

, 2018
Nitrate is not only an important nutrient but also a signaling molecule for plants. A few of key molecular components involved in primary nitrate responses have been identified mainly by forward and reverse genetics as well as systems biology, however ...
Crawford, Nigel M, Li, Na, Li, Zehui, Qi, Shengdong, Wang, Yong, Yang, Yi, Zhang, Wenjing, Zhao, Lufei   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science
The role of amino acid metabolism dysregulation in the development of type 2 diabetes remains elusive. Here, significant associations of human CREBBP/EP300 gene polymorphisms with circulating amino acid and glucose levels are reported. Through integrated
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
doaj   +1 more source

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET [PDF]

Nature Chemistry, 2014
The ability to introduce different biophysical probes into defined positions in target proteins will provide powerful approaches for interrogating protein structure, function and dynamics. However, methods for site-specifically incorporating multiple distinct unnatural amino acids are hampered by their low efficiency. Here we provide a general solution
Wang, Kaihang, Sachdeva, Amit, Cox, Daniel J., Wilf, Nabil M., Lang, Kathrin, Wallace, Stephen, Mehl, Ryan A., Chin, Jason W.   +7 more
openaire   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source