A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]
, 2008 Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A. +6 more
core +2 more sources
BMC Bioinformatics, 2017 Background DNA-binding proteins perform important functions in a great number of biological activities. DNA-binding proteins can interact with ssDNA (single-stranded DNA) or dsDNA (double-stranded DNA), and DNA-binding proteins can be categorized as ...
Wei Wang +6 more
doaj +1 more source
Nonadaptive Amino Acid Convergence Rates Decrease over Time. [PDF]
, 2015 Convergence is a central concept in evolutionary studies because it provides strong evidence for adaptation. It also provides information about the nature of the fitness landscape and the repeatability of evolution, and can mislead phylogenetic inference.
Goldstein, RA +3 more
core +1 more source
Molecular Characterization of Fluoroquinolone-Resistant Bartonella bacilliformis
Pathogens, 2021 The presence of amino acid changes in GyrA, GyrB, ParC, ParE, and in a proposed chromosomal chloramphenicol acetyl transferase (CAT), as well as mutations at 23S rRNA, were established by PCR and sequencing in 38 B.
Giovanna Mendoza-Mujica +2 more
doaj +1 more source
Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]
, 2013 Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi +75 more
core +9 more sources
Molecules, 2022 The permeation of amino acids and di-peptides with different hydrophobicities across the oil phase in W/O/W double emulsions was investigated at different concentrations, considering the pH of the aqueous phase.
Esra Kocaman +4 more
doaj +1 more source
Hachimoji DNA and RNA: A genetic system with eight building blocks [PDF]
, 2019 Reported here are DNA and RNA-like systems built from eight (hachi-) nucleotide letters (-moji) that form four orthogonal pairs. This synthetic genetic biopolymer meets the structural requirements needed to support Darwinism, including a polyelectrolyte ...
Bates, Alison M. +15 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Measurement of L-Cysteine Amino Acid Using Modified Platinum Electrode by Nickel-Aluminum layered double hydroxide [PDF]
شیمی کاربردی روز, 2019 L-Cysine (L-Cys) is one of the most important amino acids in the body and plays an important role in the immune system. In this study, the platinum electrode was modified by a Ni-Al double-layer hydroxide film (Pt /NiAlLDH) and used to measure L-Cys.
Ali Ghaffarinead +2 more
doaj +1 more source
Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits [PDF]
, 2007 The collagen prolyl 4-hydroxylases (P4Hs) are essential for proper extracellular matrix formation in multicellular organisms. The vertebrate enzymes are α2β2 tetramers, in which the β subunits are identical to protein disulfide ...
Abrams +44 more
core +1 more source