Results 21 to 30 of about 651,612 (216)

Highly selective synthesis of d-amino acids via stereoinversion of corresponding counterpart by an in vivo cascade cell factory

Microbial Cell Factories, 2021
Background d-Amino acids are increasingly used as building blocks to produce pharmaceuticals and fine chemicals. However, establishing a universal biocatalyst for the general synthesis of d-amino acids from cheap and readily available precursors with few
Dan-Ping Zhang, Xiao-Ran Jing, Lun-Jie Wu, An-Wen Fan, Yao Nie, Yan Xu   +5 more
doaj   +1 more source

The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity

Channels, 2023
In this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins.
Karen M Page, Vadim M Gumerov, Shehrazade Dahimene, Igor B Zhulin, Annette C Dolphin   +4 more
doaj   +1 more source

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Nature Communications, 2017
Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the
Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth, Paul Schimmel   +10 more
doaj   +1 more source

The physical characteristics of human proteins in different biological functions. [PDF]

PLoS ONE, 2017
The physical properties of gene products are the foundation of their biological functions. In this study, we systematically explored relationships between physical properties and biological functions.
Tengjiao Wang, Hailin Tang
doaj   +1 more source

Amino acid storage: lysosomal double role in health and disease

Autophagy Reports
Cellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance.
Aiswarya Raj, Samantha Shrihari, Urmi Bandyopadhyay   +2 more
doaj   +1 more source

Analysis and prediction of single-stranded and double-stranded DNA binding proteins based on protein sequences

BMC Bioinformatics, 2017
Background DNA-binding proteins perform important functions in a great number of biological activities. DNA-binding proteins can interact with ssDNA (single-stranded DNA) or dsDNA (double-stranded DNA), and DNA-binding proteins can be categorized as ...
Wei Wang, Lin Sun, Shiguang Zhang, Hongjun Zhang, Jinling Shi, Tianhe Xu, Keliang Li   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Molecular Characterization of Fluoroquinolone-Resistant Bartonella bacilliformis

Pathogens, 2021
The presence of amino acid changes in GyrA, GyrB, ParC, ParE, and in a proposed chromosomal chloramphenicol acetyl transferase (CAT), as well as mutations at 23S rRNA, were established by PCR and sequencing in 38 B.
Giovanna Mendoza-Mujica, Diana Flores-León, Joaquim Ruiz   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source