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Doctrine of Double Effect

The Bulletin of the Royal College of Surgeons of England, 2016
Each month we take a close look at a recent legal case with implications for the surgical profession.
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The “Double Loss” Effect: Exploring how people react to another person’s loss – the griever’s perspective [PDF]

, 2011
This study intended to explore the “double loss” effect and people’s reactions to another person’s loss. When individuals negative react to a person who is in grief there is a common tendency to avoid, provide pseudo care, and/or stiff-arm.
Bienashski, Laura
core   +1 more source

Quantum Coherence Effects in Four-level Diamond Atomic System

, 2008
A symmetric four-level closed-loop $\diamondsuit$ type (the diamond structure) atomic system driven by four coherent optical fields is investigated. The system shows rich quantum interference and coherence features. When symmetry of the system is broken,
Artoni, Balic, Bao-Quan Ou, Boozer, Brown, Brown, Burkett, Cheng-Zu Li, Dutton, Felinto, Fleischhauer, Fleischhauer, Franke-Arnold, Gavrielides, Harris, Imamoglu, Jin, Jin, Joshi, Kapale, Katz, Li, Li, Lin-Mei Liang, Massou, Matthew, Menon, Munro, Ottaviani, Rickey, Schmidt, Scully, Shubin, Walls, Walther   +34 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Symmetry causes a huge conductance peak in double quantum dots

, 2009
We predict a huge interference effect contributing to the conductance through large ultra-clean quantum dots of chaotic shape. When a double-dot structure is made such that the dots are the mirror-image of each other, constructive interference can make a
Macucci, M., Marconcini, P., Whitney, Robert S.   +2 more
core   +1 more source

Double Meanings Will Not Save the Principle of Double Effect [PDF]

Journal of Medicine and Philosophy, 2014
In an article somewhat ironically entitled "Disambiguating Clinical Intentions," Lynn Jansen promotes an idea that should be bewildering to anyone familiar with the literature on the intention/foresight distinction. According to Jansen, "intention" has two commonsense meanings, one of which is equivalent to "foresight." Consequently, questions about ...
Douglas, Charles D., Kerridge, I, Ankeny, R   +2 more
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Tunable Fano-Kondo resonance in side-coupled double quantum dot system

, 2010
We study the interference between the Fano and Kondo effects in a side-coupled double-quantum- dot system where one of the quantum dots couples to conduction electron bath while the other dot only side-couples to the first dot via antiferromagnetic (AF ...
A. C. Hewson, Chung-Hou Chung, Tsung-Han Lee   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source