Results 61 to 70 of about 2,249 (265)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
ЯВЛЕНИЕ ДВОЙНОГО ОТРИЦАНИЯ В ОСЕТИНСКОМ ЯЗЫКЕ
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 Определения термина «двойное отрицание». Явление двойного отрицания в различных языковых системах. Двойным отрицанием в осетинском языке принимается сочетание отрицательного местоимения или наречия с отрицательным глаголом, то есть глаголом с ...
Lana Vladimirovna Dzasokhova
doaj +1 more source
Double-Negation Elimination in Some Propositional Logics
Studia Logica, 2005 This article answers two questions (posed in the literature), each concerning the guaranteed existence of proofs free of double negation. A proof is free of double negation if none of its deduced steps contains a term of the form n(n(t)) for some term t, where n denotes negation.
Beeson, Michael +2 more
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Residuated Structures Derived from Commutative Idempotent Semirings
Discussiones Mathematicae - General Algebra and Applications, 2019 Since the reduct of every residuated lattice is a semiring, we can ask under what condition a semiring can be converted into a residuated lattice. It turns out that this is possible if the semiring in question is commutative, idempotent, G-simple and ...
Chajda Ivan, Länger Helmut
doaj +1 more source
Frontiers in Psychology, 2019 This investigation draws from research on negative polarity item (NPI) illusions in order to explore a new and interesting instance of misalignment observed for grammatical sentences containing two negative markers.
Iria de-Dios-Flores, Iria de-Dios-Flores
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Lightweight Double-negation Translation
EPiC Series in Computing, 2018 Deciding whether a classical theorem can be proved constructively is a well-known undecidable problem. As a consequence, any computable double-negation translation inserts some unnecessary double negations. This paper shows that most of these unnecessary insertions can be avoided without any use of constructive proof search techniques. For this purpose,
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source