Results 111 to 120 of about 1,209,458 (341)

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. [PDF]

, 2019
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Coskun, Ayse K, Deeks, Steven, Gonzalo-Gil, Elena, Ikediobi, Uchenna, Lampkin, Teagan D, Leibowitz, Rebecca, Marconi, Vincent C, Mehta, Sameet, Porterfield, J Zachary, Rapuano, Patrick B, Rimland, David, Sutton, Richard E, Walker, Bruce D   +12 more
core  

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Arrhythmogenic right ventricular cardiomyopathy: considerations from in silico experiments

Frontiers in Physiology, 2012
Objective: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with remodelling of gap junctions and also, although less well-defined, down-regulation of the fast sodium current. The gap junction remodelling and down-regulation of sodium
Ronald eWilders
doaj   +1 more source

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +3 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Monoterpene regulation of Ras and Ras-related protein expression

Journal of Lipid Research, 2003
Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined.
Sarah A. Holstein, Raymond J. Hohl
doaj  

Stressful life events are associated with low secretion rates of immunoglobulin A in saliva in the middle aged and elderly [PDF]

, 2006
Whether chronic stress experience is related to down-regulation of secretory immunoglobulin A (S-IgA) was tested in two substantial cohorts, one middle-aged (N = 640) and one elderly (N = 582), comprising similar numbers of men (N = 556) and women (N ...
Phillips, A.C., Carroll, D., Evans, P., Bosch, J.A., Clow, A., Hucklebridge, F., Der, G., Phillips, A.C., Carroll, D., Evans, P., Bosch, J.A., Clow, A., Hucklebridge, F., Der, G.   +13 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Editorial: Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets

Frontiers in Oncology, 2022
João Pessoa, Marta Martins, Sandra Casimiro, Carlos Pérez-Plasencia, Varda Shoshan-Barmatz   +4 more
doaj   +1 more source