Results 71 to 80 of about 1,249,164 (307)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Distribusi Penderita Sindrom Down Berdasarkan Analisis Sitogenetika Di Laboratorium CEBIOR [PDF]
, 2015 Background : Down syndrome is a condition when a person has an extra number of chromosomes 21 in the form of either classical trisomy 21, translocation or mosaic.
Berlinda, Impi +2 more
core +2 more sources
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018 Introduction People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS.
Alain D. Dekker +16 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2020 Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS.
David Mengel +10 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
iScienceSummary: Individuals with Down syndrome (DS), caused by trisomy of chromosome 21 (chr21, T21), are strongly predisposed to Alzheimer’s disease (AD), due to triplication of the APP gene, with ∼100% penetrance of AD brain pathology by age 40 and variable ...
Paula Araya +15 more
doaj +1 more source
Web Untuk Deteksi Dini Tingkat Retardasi Down Syndrome Pada Anak [PDF]
, 2015 Down Syndrome is a condition of physical and mental development's retardation in children that caused by abnormalities in the development of the chromosome. However, behind the special needs held by children with Down syndrome, they have a chance to live
Leonita, C. (Christine) +1 more
core
Evaluation of a usability testing guide for mobile applications focused on people with Down syndrome (USATESTDOWN) [PDF]
, 2016 Usability testing of mobile applications involving people with Down syndrome is an issue that has not been comprehensively investigated. There is no single proposal that takes on board all the issues that could potentially be taken into account to deal ...
Alamán Roldán, Xavier +5 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
, 2013 People with Down syndrome, a frequent genetic disorder in humans, have increased risk of health problems associated with this condition. One clinical feature of Down syndrome is the increased prevalence and severity of periodontal disease in comparison ...
Cabras, Tiziana +7 more
core +1 more source