Results 81 to 90 of about 1,249,164 (307)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders
Frontiers in Genetics, 2019 Evidence from multiple laboratories has accumulated to show that mosaic neuronal aneuploidy and consequent apoptosis characterizes and may underlie neuronal loss in many neurodegenerative diseases, particularly Alzheimer’s disease and frontotemporal ...
Huntington Potter +12 more
doaj +1 more source
HUBUNGAN LINGKAR KEPALA DENGAN PERKEMBANGAN ANAK SINDROM DOWN [PDF]
, 2015 Background: Down syndrome is congenital disease caused by abnormalities in 21st chromosome. Small head circumference and developmental delay are characteristics of children with Down Syndrome.
Purwanti, Asri, Sishadi, Arla Santika
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Epileptic spasms in individuals with Down syndrome: A review of the current literature
Epilepsia Open, 2020 Epilepsy can occur in individuals with Down syndrome (DS), with epileptic spasms representing the most frequent seizure type in this population. Epileptic spasms can have devastating consequences on the development of individuals with the condition. This
Daniel J. Kats +2 more
doaj +1 more source
PENERIMAAN DIRI ORANG TUA YANG MEMILIKI ANAK DOWN SYNDROME [PDF]
, 2016 Orang tua yang memiliki anak down syndrome tidak semuanya mengalami dan merasakan hal yang sama terhadap kehadiran anaknya yang down syndrome, ada beberapa orang tua yang menerima anaknya dengan segala kekurangannya sedangkan ada juga orang tua yang ...
Dekalia Yulistiani
core
Use of recombinant human bone morphogenetic protein for revision cervical spine fusion in children with Down syndrome: a case series [PDF]
, 2020 Lara Langer Cohen +5 more
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
F1000Research, 2016 In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at ...
Annette Karmiloff-Smith +11 more
doaj +1 more source