Results 11 to 20 of about 453,301 (335)

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia [PDF]

Mediators of Inflammation, 2015
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate the role that autophagy plays in cerebral ischemia.
Yang Yang, Keqiang Gao, Zhiying Hu, Weiyun Li, Henry Davies, Shucai Ling, John A. Rudd, Marong Fang   +7 more
doaj   +3 more sources

SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1

Cell Death Discovery, 2022
SMYD2, as an oncogene, has been involved in multiple types of cancer, but the potential role of SMYD2 in gastrointestinal stromal tumors (GIST) remains enigmatic and requires further investigation.
Yong Ji, Xiaofeng Xu, Cong Long, Jianjiang Wang, Li Ding, Zhizhong Zheng, Huiping Wu, Liu Yang, Lan Tao, Feng Gao   +9 more
doaj   +3 more sources

NagPIBAF upregulation and ompO downregulation compromise oxidative stress tolerance of Stenotrophomonas maltophilia

BMC Microbiology
Background Outer membrane protein OmpA is composed of two domains, an N-terminal β-barrel structure embedded in the outer membrane and a C-terminal globular domain noncovalently associated with the peptidoglycan layer in periplasm.
Tsuey-Ching Yang, Shao-Chi Wu, Ting-Yu Yeh, Hsu-Feng Lu, Yi-Tsung Lin, Li-Hua Li   +5 more
doaj   +3 more sources

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα [PDF]

Cell Death & Disease, 2021
AbstractDuplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precocious puberty with hyperandrogenism, suggesting increased MeCP2 may cause male hyperandrogenism ...
Yu-Meng Wang, Yu Wu, Yu-Fang Zheng, Hong-Yan Wang   +3 more
openaire   +3 more sources

Downregulation of MEG3 and upregulation of EZH2 cooperatively promote neuroblastoma progression [PDF]

Journal of Cellular and Molecular Medicine, 2022
AbstractNeuroblastoma (NB), an embryonic tumour originating from sympathetic crest cells, is the most common extracranial solid tumour type in children with poor overall prognosis. Accumulating evidence has demonstrated the involvement of long non‐coding RNA (lncRNA) in numerous biological processes and their associations with embryonic development and
Mujie Ye, Runnan Gao, Shiyu Chen, Meng Wei, Jing Wang, Bowen Zhang, Suwen Wu, Yuexin Xu, Peixuan Wu, Xin Chen, Jing Ma, Duan Ma, Kuiran Dong   +12 more
openaire   +2 more sources

Hepatitis C Virus Infection Upregulates Plasma Phosphosphingolipids and Endocannabinoids and Downregulates Lysophosphoinositols

International Journal of Molecular Sciences, 2023
A mass spectrometry-based lipidomic investigation of 30 patients with chronic hepatitis C virus (HCV) infection and 30 age- and sex-matched healthy blood donor controls was undertaken. The clustering and complete separation of these two groups was found by both unsupervised and supervised multivariate data analyses. Three patients who had spontaneously
Diren Beyoğlu, Stephanie Schwalm, Nasser Semmo, Andrea Huwiler, Jeffrey R. Idle   +4 more
openaire   +3 more sources

Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach [PDF]

International Journal of Molecular Sciences, 2019
Probiotics are used in the management of some gastrointestinal diseases. However, little is known about their effects on normal gastric epithelial biology. The aim of this study was to explore how the probiotic mixture VSL#3 affects gastric cell lineages in mice with a special focus on protective and aggressive factors.
Khoder, Ghalia, Al-Yassir, Farah, Al Menhali, Asma, Saseedharan, Prashanth, Sugathan, Subi, Tomasetto, Catherine-Laure, Karam, Sherif   +6 more
openaire   +3 more sources

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts [PDF]

Journal of Investigative Dermatology, 2008
Acutely transforming retrovirus AKT8 in rodent T-cell lymphoma (Akt) is a serine/threonine kinase that plays important roles in survival, cell-cycle progression, and cell proliferation, and has recently been implicated in collagen regulation. The aim of this study was to determine the role of Akt in collagen deposition by normal dermal fibroblasts, and
Bujor, Andreea M., Pannu, Jaspreet, Bu, Shizhong, Smith, Edwin A., Muise-Helmericks, Robin C., Trojanowska, Maria   +5 more
openaire   +2 more sources

Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p

Bioscience of Microbiota, Food and Health, 2022
Oxidative stress is associated with aging and pathologies such as cardiovascular diseases, Alzheimer's disease, and cancer. Glutathione S-transferase (GST), a family of detoxification enzymes, plays a crucial role in countering oxidative stress. Therefore, there is a need for the development of physiologically functional foods and agricultural products,
MARUGAME, Yuki, TAKESHITA, Natsuko, YAMADA, Shuhei, YOSHITOMI, Ren, KUMAZOE, Motofumi, FUJIMURA, Yoshinori, TACHIBANA, Hirofumi   +6 more
openaire   +3 more sources

Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm

Advances in Clinical and Experimental Medicine, 2020
Thoracic aortic aneurysm (TAA) formation is accompanied by degradation of extracellular matrix components (EMC). Numerous matrix metalloproteinases (MMPs) have been implicated in the process, but the involvement of MMP-3 remains unclear. Additionally, the changes in proteoglycan (PG) structure can alter the signal transduction pathways in TAA, though ...
Małgorzata Matusiewicz, Maciej Rachwalik, Małgorzata Krzystek-Korpacka, Grzegorz Bielicki, Izabela Berdowska, Rafał Nowicki, Andrzej Gamian, Marek Jasiński   +7 more
openaire   +2 more sources