Results 11 to 20 of about 462,684 (373)
Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3 [PDF]
PLOS ONE, 2016 Potential benefits of statins in the treatment of chronic kidney disease beyond lipid-lowering effects have been described. However, molecular mechanisms involved in renoprotective actions of statins have not been fully elucidated.
Thiago Bruder‐Nascimento +10 more
semanticscholar +6 more sources
Downregulation of GSK3β and Upregulation of URG7 in Hepatitis B-Related Hepatocellular Carcinoma
Hepatitis Monthly, 2020 : Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). The exact molecular contributors to the development of HBV-related HCC are not yet completely understood.
D. Javanmard +13 more
semanticscholar +4 more sources
Experimental and Therapeutic Medicine, 2016 The present study aimed to investigate the effects of microRNA (miRNA/miR)-497 expression levels on the expression levels of synuclein γ (SNCG) in serum samples, as well as osteosarcoma and lung-metastatic tissue samples, from patients with osteosarcoma.
Liangjun Wang +3 more
semanticscholar +4 more sources
SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1
Cell Death Discovery, 2022 SMYD2, as an oncogene, has been involved in multiple types of cancer, but the potential role of SMYD2 in gastrointestinal stromal tumors (GIST) remains enigmatic and requires further investigation.
Yong Ji +9 more
doaj +3 more sources
Molecular Medicine Reports, 2017 MicroRNAs (miRNAs) have been investigated widely as key regulators of gene expression in different diseases by affecting the miRNA-mediated regulatory function.
G. Zhang +3 more
semanticscholar +5 more sources
Upregulation of ADAMTS-7 and downregulation of COMP are associated with aortic aneurysm
Molecular Medicine Reports, 2017 Aortic aneurysm (AA) remains a fatal condition with high rates of morbidity and mortality, and the associated underlying mechanism influencing its pathology remains to be elucidated. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑7 has previously been demonstrated to be involved in the pathogenesis of vascular atherosclerosis ...
Wei Qin +4 more
openalex +4 more sources
BMC MicrobiologyBackground Outer membrane protein OmpA is composed of two domains, an N-terminal β-barrel structure embedded in the outer membrane and a C-terminal globular domain noncovalently associated with the peptidoglycan layer in periplasm.
Tsuey-Ching Yang +5 more
doaj +3 more sources
MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα [PDF]
Cell Death & Disease, 2021 AbstractDuplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precocious puberty with hyperandrogenism, suggesting increased MeCP2 may cause male hyperandrogenism ...
Yu Wu +4 more
openaire +4 more sources
Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis [PDF]
, 2013 Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of ...
Filkor, Katalin +6 more
core +16 more sources
TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9
iScience, 2021 Summary: We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect of NIK ...
Jinming Zhao +10 more
doaj +1 more source