Results 41 to 50 of about 378,928 (303)

Correction to: Common bean resistance to Xanthomonas is associated with upregulation of the salicylic acid pathway and downregulation of photosynthesis

, 2020
Correction to Common bean resistance to Xanthomonas is associated with upregulation of the salicylic acid pathway and downregulation of photosynthesis (vol 21, 566, 2020) ; WOS:000575201800005International ...
Foucher, Justine, Chen, Nicolas W. G., Ruh, Mylène, Pelletier, Sandra, Preveaux, Anne, Jacques, Marie-Agnès, Carrere, Sébastien, Briand, Martial, Serre, Rémy-Félix   +8 more
core   +1 more source

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts [PDF]

Journal of Investigative Dermatology, 2008
Acutely transforming retrovirus AKT8 in rodent T-cell lymphoma (Akt) is a serine/threonine kinase that plays important roles in survival, cell-cycle progression, and cell proliferation, and has recently been implicated in collagen regulation. The aim of this study was to determine the role of Akt in collagen deposition by normal dermal fibroblasts, and
Bujor, Andreea M., Pannu, Jaspreet, Bu, Shizhong, Smith, Edwin A., Muise-Helmericks, Robin C., Trojanowska, Maria   +5 more
openaire   +2 more sources

CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone

Molecular Medicine Reports, 2022
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies and primarily presents with hyperandrogenism. Although environmental factors and genetic factors are thought to be the major reason, there still exists a lot of questions need to be answered. High expression of C‑terminal‑binding protein 1 antisense (CTBP1‑AS) was identified as
Wen, Mingxiao, Dou, Xiaoqing, Zhang, Shuzhen, Wang, Bin, Xu, Jiangyan, Zhang, Wenchao, Wang, Feifei   +6 more
openaire   +2 more sources

Altitudinal Variation of Metabolites, Mineral Elements and Antioxidant Activities of Rhodiola crenulata (Hook.f. & Thomson) H.Ohba

Molecules, 2021
Rhodiolacrenulata (Hook.f. & Thomson) H.Ohba is an alpine medicinal plant that can survive in extreme high altitude environments. However, its changes to extreme high altitude are not yet clear.
Tingting Dong, Yueqi Sha, Hairong Liu, Liwei Sun   +3 more
doaj   +1 more source

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells

, 2020
Dexamethasone (DEX), a synthetic glucocorticoid, is commonly used as immunosuppressive and chemotherapeutic agent. This study was undertaken to investigate the effects of DEX on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced ...
Jong-Wook Park, Peter Kubatka, Sang Hyun Kim, Seon Min Woo, Ju-Ock Nam, Mi-Yeon Jeon, Shin Kim, Kyoung-jin Min, Seung Un Seo, Taeg Kyu Kwon   +9 more
core   +1 more source

LncRNA MEG3 targets miR-21 to mediate TLR4/NF-κB pathway and alleviate myocardial ischemia-reperfusion injury in mice

Shiyong laonian yixue
[Objective] To observe the effect of long non-coding ribonucleic acid human maternal expressed gene 3 (LncRNA MEG3) targeting microribonuclease-21 (miR-21) mediating Toll like receptor 4 (TLR4) and nuclear factor-κB (NF-κB) pathway on myocardial ischemia-
XING Zhi, Shajidan Abudureyimu, Palida Abulaiti, WANG Yu, LYU Maolin, GAO Ying   +5 more
doaj   +1 more source

Manipulation of Cannabinoid Biosynthesis via Transient RNAi Expression

Frontiers in Plant Science, 2021
Cannabis sativa L. produces unique phytocannabinoids, which are used for their pharmaceutical benefits. To date, there are no reports of in vivo engineering targeting the cannabinoid biosynthesis genes to greater elucidate the role each of these genes ...
Lennon Matchett-Oates, Lennon Matchett-Oates, German C. Spangenberg, German C. Spangenberg, Noel O. I. Cogan, Noel O. I. Cogan   +5 more
doaj   +1 more source

Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti‑hyperglycemic effects of proanthocyanidins

Medicine International, 2022
Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced hyperglycemia and to clarify the underlying molecular mechanisms underlying its effects. For this purpose, 60
El-Ashmawy, Nahla E., Khedr, Eman G., Alfeky, Nehal H., Ibrahim, Amera O.   +3 more
openaire   +2 more sources

LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis

BMC Cancer, 2020
Background Long noncoding RNAs (lncRNAs) have been reported to be important regulators in pathogenesis of human cancers, including nasopharyngeal carcinoma (NPC). Here, we mainly aimed to explore the mechanisms of LncRNA-SNHG5/ miR-1179/HMGB3 axis in NPC
Dengtao Liu, Yanpeng Wang, Yigang Zhao, Xiao Gu   +3 more
doaj   +1 more source

Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3 [PDF]

PLOS ONE, 2016
Potential benefits of statins in the treatment of chronic kidney disease beyond lipid-lowering effects have been described. However, molecular mechanisms involved in renoprotective actions of statins have not been fully elucidated. We questioned whether statins influence development of diabetic nephropathy through reactive oxygen species, RhoA and Akt ...
Bruder-Nascimento, Thiago, Callera, Glaucia, Montezano, Augusto, Antunes, Tayze T., He, Ying, Nguyen Dinh Cat, Aurelie, Ferreira, Nathanne S., Barreto, Pedro A., Olivon, Vânia C., Tostes, Rita C., Touyz, Rhian   +10 more
openaire   +4 more sources