Results 21 to 30 of about 378,928 (303)

miR-382-5p promotes cell invasion in hepatocellular carcinoma by targeting PTEN to activate PI3K/Akt signaling pathway

World Journal of Surgical Oncology, 2022
Purpose This study aimed at investigating miR-382-5p expression in tissues and cell lines with hepatocellular carcinoma (HCC), its effects on the invasion of HCC cells, and related mechanisms.
Bo Lv, Xianzhuo Liu, Xinfeng Zhu, Min Huang   +3 more
doaj   +1 more source

Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach [PDF]

International Journal of Molecular Sciences, 2019
Probiotics are used in the management of some gastrointestinal diseases. However, little is known about their effects on normal gastric epithelial biology. The aim of this study was to explore how the probiotic mixture VSL#3 affects gastric cell lineages in mice with a special focus on protective and aggressive factors.
Khoder, Ghalia, Al-Yassir, Farah, Al Menhali, Asma, Saseedharan, Prashanth, Sugathan, Subi, Tomasetto, Catherine-Laure, Karam, Sherif   +6 more
openaire   +3 more sources

Arecoline induces dual modulation of blood pressure in rat, including an initial downregulation and a subsequent upregulation [PDF]

, 2020
Purpose: To determine the role of arecoline in cardiovascular modulation in rats.Methods: After rats were anaesthetized with intraperitoneal urethane (1.4 g/kg body weight), saline or arecoline (at doses of 1.0, 3.0 and 10.0 mg/kg) was intraperitoneally ...
Fu, Jiangliu, Ye, Xiaowen, Jiang, Xiaoxia, Deng, Meiping, Zhou, Peiling, Wu, Jiashan, Chen, Lijuan, Zhang, Changzheng   +7 more
core   +1 more source

Moscatilin suppresses the inflammation from macrophages and T cells

Open Medicine, 2022
In this study, we aim to investigate moscatilin in alleviating symptoms of autoimmune liver disease (ALD) in a concanavalin A (ConA)-induced liver injury mouse model and elucidate the underlying mechanisms.
Zhang Ying, Xu Yugang, Jing Xiujie, Lu Wenkui, Zhang Fusen, Qin Chengkun   +5 more
doaj   +1 more source

IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells

Cancer Cell International, 2021
Background Interferon regulatory factor-1 (IRF1) affects the proliferation of colorectal cancer (CRC). Recombinant interferon inducible protein 35 (IFI35) participates in immune regulation and cell proliferation.
Yan Hu, Bing Wang, Ke Yi, Qingjun Lei, Guanghui Wang, Xiaohui Xu   +5 more
doaj   +1 more source

SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer. [PDF]

PLoS ONE, 2015
SALL4 plays important roles in the development and progression of many cancers. However, the role and molecular mechanism of SALL4 in endometrial cancer remain elusive.
Lei Liu, Jing Zhang, Xiaoming Yang, Chi Fang, Huali Xu, Xiaowei Xi   +5 more
doaj   +1 more source

Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm

Advances in Clinical and Experimental Medicine, 2020
Thoracic aortic aneurysm (TAA) formation is accompanied by degradation of extracellular matrix components (EMC). Numerous matrix metalloproteinases (MMPs) have been implicated in the process, but the involvement of MMP-3 remains unclear. Additionally, the changes in proteoglycan (PG) structure can alter the signal transduction pathways in TAA, though ...
Małgorzata Matusiewicz, Maciej Rachwalik, Małgorzata Krzystek-Korpacka, Grzegorz Bielicki, Izabela Berdowska, Rafał Nowicki, Andrzej Gamian, Marek Jasiński   +7 more
openaire   +2 more sources

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

iScience, 2023
Cisplatin resistance remains a major obstacle limiting the effectiveness of chemotherapy in cervical cancer. However, the underlying mechanism of cisplatin resistance is still unclear. In this study, we demonstrate that vacuolar protein sorting 13 homolog C (VPS13C) deficiency promotes cisplatin resistance in cervical cancer.
Xiangyu Tan, Xueqian Wang, Xueyao Liao, Xin Wang, Zhichao Jiang, Wenjia Liang, Chen Cao, Danni Gong, Zheng Hu, Xun Tian   +9 more
openaire   +3 more sources

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion

Molecular Medicine Reports, 2019
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS‑7) has been revealed to serve an important role in inflammation‑associated diseases. However, the role of ADAMTS‑7 in spontaneous abortion (SA) remains unclear. In the present study, human and mouse decidual tissues were used to detect the expression of ADAMTS‑7 and cartilage ...
Mu, Yang, Zhou, Dan-Ni, Yan, Na-Na, Ding, Jin-Li, Yang, Jing   +4 more
openaire   +3 more sources

Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2020
Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang, Wei Zhang, Weiduo Hou, Weiduo Hou, Mo Chen, Erman Chen, Erman Chen, Deting Xue, Deting Xue, Chenyi Ye, Chenyi Ye, Weixu Li, Weixu Li, Zhijun Pan, Zhijun Pan   +14 more
doaj   +1 more source