Results 11 to 20 of about 378,928 (303)
Molecules, 2020 Magnolol is a biologically active compound, isolated from the Chinese herb Magnolia, that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic activities.
Taeg Kyu Kwon +2 more
exaly +4 more sources
Molecules, 2018 Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-
Dong-Eun Kim, Shin Kim, Yung Hyun Choi
exaly +4 more sources
Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia [PDF]
Mediators of Inflammation, 2015 It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate the role that autophagy plays in cerebral ischemia.
Yang Yang +7 more
doaj +3 more sources
TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9 [PDF]
iScience, 2021 Summary: We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect of NIK ...
Jinming Zhao +10 more
doaj +2 more sources
Chlorogenic Acid Ameliorates Liver Function in Association with Bax Downregulation, P53 Downregulation and Bcl-2 Upregulation in Diabetic Wistar Rat [PDF]
BIO Web of Conferences, 2022 Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions in the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive apoptosis leads to liver dysfunction.
Setyaningsih Mayang +3 more
doaj +2 more sources
International Journal of Molecular Sciences, 2022 Glioblastoma (GBM) is the most frequent and lethal primary malignant brain tumor. Despite decades of research, therapeutic advances that significantly prolong life are non-existent. In recent years, microRNAs (miRNAs) have been a focus of study in the pathobiology of cancer because of their ability to simultaneously regulate multiple genes.
Elizabeth Q. X. Mulcahy +7 more
openaire +3 more sources
MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα [PDF]
Cell Death & Disease, 2021 AbstractDuplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precocious puberty with hyperandrogenism, suggesting increased MeCP2 may cause male hyperandrogenism ...
Yu-Meng Wang +3 more
openaire +3 more sources
Downregulation of MEG3 and upregulation of EZH2 cooperatively promote neuroblastoma progression [PDF]
Journal of Cellular and Molecular Medicine, 2022 AbstractNeuroblastoma (NB), an embryonic tumour originating from sympathetic crest cells, is the most common extracranial solid tumour type in children with poor overall prognosis. Accumulating evidence has demonstrated the involvement of long non‐coding RNA (lncRNA) in numerous biological processes and their associations with embryonic development and
Mujie Ye +12 more
openaire +2 more sources
Machine learning on thyroid disease: a review
Frontiers in Bioscience-Landmark, 2022 This study reviews the recent progress of machine learning for the early diagnosis of thyroid disease. Based on the results of this review, different machine learning methods would be appropriate for different types of data for the early diagnosis of ...
Kwang-Sig Lee, Hyuntae Park
doaj +1 more source
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation [PDF]
Kidney International, 2006 Loss of function of the peritoneal membrane is associated with peritonitis. Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects. Our aim was to elucidate the regulatory role of adenosine during peritonitis and to test the involvement of peritoneal mesothelial cells (PMC) in adenosine regulation.
Rogachev, B. +6 more
openaire +2 more sources