Results 31 to 40 of about 378,928 (303)
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]
, 2010 Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy +14 more
core +1 more source
Experimental and Molecular Medicine, 2023 Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood.
Hyejin Kwon +8 more
doaj +1 more source
Upregulation of ADAMTS-7 and downregulation of COMP are associated with aortic aneurysm
Molecular Medicine Reports, 2017 Aortic aneurysm (AA) remains a fatal condition with high rates of morbidity and mortality, and the associated underlying mechanism influencing its pathology remains to be elucidated. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑7 has previously been demonstrated to be involved in the pathogenesis of vascular atherosclerosis ...
Qin, Wei +4 more
openaire +3 more sources
Biomedicines, 2021 To elucidate the effects of switching a PGF2α agonist, bimatoprost acid (BIM-A), to an EP2 agonist (Omidenepag—OMD; butaprost—Buta) or reversing the switching on adipose tissue, two-dimensional (2D) and three-dimensional (3D) cultures of 3T3-L1 cells ...
Yosuke Ida +5 more
doaj +1 more source
, 2023 Table showing gene categories, protein, and gene symbols, analyzed proteins/genes, gene name, function, and their upregulation and downregulation in condition: uninfected, EM infected and IOE infected.
Aditya Kumar Sharma (6475922) +2 more
core +1 more source
Tumor Biology, 2014 Nucleostemin (NS) is a nucleolar protein involved in stem cell (SC) self-renewal by controlling cell cycle progression. In addition to SCs, NS is also expressed in some highly proliferating cells including several adult stem cells and cancer cell lines.
Malek Hossein, Asadi +2 more
openaire +2 more sources
Downregulation of α-galactosidase A upregulates CD77: functional impact for Fabry nephropathy [PDF]
Kidney International, 2009 Anderson-Fabry disease, an inherited deficiency in the lysosomal enzyme alpha-galactosidase A, is characterized by the progressive accumulation of globotriaosylceramide (Gb3), also known as CD77. We sought to clarify the pathogenesis of Fabry disease by establishing a cell model of this disorder.
Thomaidis, Thomas +6 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2021 Shank2 is an abundant postsynaptic scaffolding protein that is known to regulate excitatory synapse assembly and synaptic transmission and has been implicated in various neurodevelopmental disorders, including autism spectrum disorders (ASD).
Seungjoon Lee +6 more
doaj +1 more source
Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients [PDF]
Translational Psychiatry, 2012 Increasing evidence suggests that epigenetic dysfunction may account for the alteration of gene transcription present in neuropsychiatric disorders such as schizophrenia (SZ), bipolar disorder (BP) and autism. Here, we studied the expression of the ten-eleven translocation (TET) gene family and activation-induced deaminase/apolipoprotein B mRNA-editing
Dong, E, Gavin, D P, Chen, Y, Davis, J
openaire +2 more sources
Differential expression of microRNAs in mouse liver under aberrant energy metabolic status[S]
Journal of Lipid Research, 2009 Despite years of effort, exact pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains obscure. To gain an insight into the regulatory roles of microRNAs (miRNAs) in aberrant energy metabolic status and pathogenesis of NAFLD, we analyzed the ...
Shengjie Li +8 more
doaj +1 more source