Results 51 to 60 of about 378,928 (303)

TCDD-mediated upregulation or downregulation of miRs and their role in cancer.

, 2013
TCDD-mediated upregulation or downregulation of miRs and their role in cancer.
Prakash Nagarkatti (307507), Hongbing Guan (248324), Narendra P. Singh (209641), Udai P. Singh (209647), Mitzi Nagarkatti (209661)   +4 more
core   +1 more source

Downregulation of miR-140-3p Contributes to Upregulation of CD38 Protein in Bronchial Smooth Muscle Cells

, 2020
In allergic bronchial asthma, an increased smooth muscle contractility of the airways is one of the causes of the airway hyperresponsiveness (AHR).
Mayumi Matsumoto, Motohiko Hanazaki, Yoshihiko Chiba, Hiroyasu Sakai   +3 more
core   +1 more source

LncRNAMORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93 [PDF]

BMC Cardiovascular Disorders, 2020
Abstract Background Myocardial infarction (MI) affects the expression of a large number of lncRNAs, while the functions of those dysregulated lncRNAs are mostly unclear. Materials and methods Expression of MORT and miR-93 in hearth tissues and plasma of both MI mice and Sham mice and both MI patients and healthy controls was detected by RT-qPCR ...
Jing Lv, Yi Zhu, Shanglong Yao
openaire   +3 more sources

The DEGs exhibit either upregulation, downregulation, swing patterns between life stages.

, 2019
(A) The DEGs with upregulation profile in duck life cycle. (B) The DEGs with downregulation profile in duck life cycle. (C) The DEGs with swing patterns in duck life cycle.
Li Chen (5749), Jianhong Hu (140402), Jindong Ren (1781794), Lizhi Lu (467442), Xuetao Huang (6876299), Changsen Sun (431992), Xiaolin Liu (403100)   +6 more
core   +1 more source

Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

Regenerative Therapy
Background: This study investigated the molecular mechanism by which the combination of platelet-rich plasma (PRP) and isometric contraction of the quadriceps (ICQ) intervention regulates autophagy in chondrocytes to prevent and treat knee osteoarthritis
Liang Cheng, Shuwan Chang, Yajun Tan, Benxiang He   +3 more
doaj   +1 more source

MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma

Journal of Pharmacological Sciences, 2010
.: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of experimental ...
Yoshihiko Chiba, Miwa Misawa
doaj   +1 more source

SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma. [PDF]

PLoS ONE, 2015
Hodgkin's lymphoma (HL) is a lymphoid neoplasm characterized by Hodgkin's and Reed-Sternberg (H/RS) cells, which is regulated by CD99. We previously reported that CD99 downregulation led to the transformation of murine B lymphoma cells (A20) into cells ...
Wenjing Jian, Lin Zhong, Jing Wen, Yao Tang, Bo Qiu, Ziqing Wu, Jinhai Yan, Xinhua Zhou, Tong Zhao   +8 more
doaj   +1 more source

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation

, 2021
A lucanthone, one of the family of thioxanthenones, has been reported for its inhibitory effects of apurinic endonuclease-1 and autophagy. In this study, we investigated whether lucanthone could enhance tumor necrosis factor-related apoptosis-inducing ...
Ji Yun Yoon, Seon Min Woo, Seul Gi Lee, Seung Un Seo, So Rae Song, Taeg Kyu Kwon   +5 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet

Frontiers in Genetics, 2020
Manganese (Mn), primarily acquired through diet, is required for brain function and development. Epidemiological studies have found an association between both low and high levels of Mn and impaired neurodevelopment in children.
Young Ah Seo, Eun-Kyung Choi, Luisa Aring, Molly Paschall, Shigeki Iwase   +4 more
doaj   +1 more source