Results 21 to 30 of about 462,684 (373)
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation [PDF]
Kidney International, 2006 Loss of function of the peritoneal membrane is associated with peritonitis. Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects. Our aim was to elucidate the regulatory role of adenosine during peritonitis and to test the involvement of peritoneal mesothelial cells (PMC) in adenosine regulation.
Nadav Y. Ziv +6 more
openaire +3 more sources
Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach [PDF]
International Journal of Molecular Sciences, 2019 Probiotics are used in the management of some gastrointestinal diseases. However, little is known about their effects on normal gastric epithelial biology. The aim of this study was to explore how the probiotic mixture VSL#3 affects gastric cell lineages in mice with a special focus on protective and aggressive factors.
Prashanth Saseedharan +7 more
openaire +4 more sources
World Journal of Surgical Oncology, 2022 Purpose This study aimed at investigating miR-382-5p expression in tissues and cell lines with hepatocellular carcinoma (HCC), its effects on the invasion of HCC cells, and related mechanisms.
Bo Lv +3 more
doaj +1 more source
Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response
Frontiers in Immunology, 2022 Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding mechanisms of resistance to immunotherapy and how anti-tumor immune response can be therapeutically ...
Brandie C Taylor, J. Balko
semanticscholar +1 more source
Molecules, 2020 Magnolol is a biologically active compound, isolated from the Chinese herb Magnolia, that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic activities.
Seon Min Woo +2 more
doaj +1 more source
Moscatilin suppresses the inflammation from macrophages and T cells
Open Medicine, 2022 In this study, we aim to investigate moscatilin in alleviating symptoms of autoimmune liver disease (ALD) in a concanavalin A (ConA)-induced liver injury mouse model and elucidate the underlying mechanisms.
Zhang Ying +5 more
doaj +1 more source
Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm
Advances in Clinical and Experimental Medicine, 2020 Thoracic aortic aneurysm (TAA) formation is accompanied by degradation of extracellular matrix components (EMC). Numerous matrix metalloproteinases (MMPs) have been implicated in the process, but the involvement of MMP-3 remains unclear. Additionally, the changes in proteoglycan (PG) structure can alter the signal transduction pathways in TAA, though ...
Malgorzata Matusiewicz +8 more
openaire +2 more sources
IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
Cancer Cell International, 2021 Background Interferon regulatory factor-1 (IRF1) affects the proliferation of colorectal cancer (CRC). Recombinant interferon inducible protein 35 (IFI35) participates in immune regulation and cell proliferation.
Yan Hu +5 more
doaj +1 more source
Downregulation of α-galactosidase A upregulates CD77: functional impact for Fabry nephropathy [PDF]
Kidney International, 2009 Anderson-Fabry disease, an inherited deficiency in the lysosomal enzyme alpha-galactosidase A, is characterized by the progressive accumulation of globotriaosylceramide (Gb3), also known as CD77. We sought to clarify the pathogenesis of Fabry disease by establishing a cell model of this disorder.
Thomas Thomaidis +6 more
openaire +3 more sources
SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer. [PDF]
PLoS ONE, 2015 SALL4 plays important roles in the development and progression of many cancers. However, the role and molecular mechanism of SALL4 in endometrial cancer remain elusive.
Lei Liu +5 more
doaj +1 more source