Results 21 to 30 of about 453,301 (335)

LINC01012 upregulation promotes cervical cancer proliferation and migration via downregulation of CDKN2D

Oncology Letters, 2023
The incidence and mortality of cervical cancer (CC) rank fourth among those of all gynecological malignancies. Long noncoding RNAs (lncRNAs) serve important roles in the development of various types of cancer. The aim of the present study was to explore the role of lncRNAs in the pathogenesis of CC and to identify novel therapeutic targets.
Zhang, Keyi, Ni, Xiao, Ma, Xiaoling, Sun, Rui, Qiu, Jiangnan, Luo, Chengyan   +5 more
openaire   +2 more sources

Geraniol Inhibits Endometrial Carcinoma via Downregulating Oncogenes and Upregulating Tumour Suppressor Genes [PDF]

Indian Journal of Clinical Biochemistry, 2016
Endometrial carcinoma is the fourth most abundant cancer worldwide in women. Female Wistar rats were segregated into five groups: group I-control, group II-MNNG (N-methyl-N'-nitro-N-nitrosoguanidine-150 mg/kg) administered through intravaginal detention of cotton absorbent, group III-geraniol (GOH) only, group IV-GOH-pretreated (7 days before the start
Sakkaravarthy Shanmugapriya, Perumal Subramanian, Sivamani Kanimozhi   +2 more
openaire   +2 more sources

Microarray-based screening of differentially expressed genes of E. coli O157:H7 Sakai during preharvest survival on butterhead lettuce [PDF]

, 2016
Numerous outbreaks of Escherichia coli O157:H7 have been linked to the consumption of leafy vegetables. However, up to the present, little has been known about E.
Cottyn, Bart, Heyndrickx, Marc, Holden, Nicola, Maes, Martine, Uyttendaele, Mieke, Van der Linden, Inge, Vlaemynck, Geertrui   +6 more
core   +3 more sources

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP

Molecules, 2018
Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-
Mi-Yeon Jeon, Kyoung-jin Min, Seon Min Woo, Seung Un Seo, Yung Hyun Choi, Sang Hyun Kim, Dong Eun Kim, Tae-Jin Lee, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon   +10 more
doaj   +1 more source

Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation [PDF]

Kidney International, 2006
Loss of function of the peritoneal membrane is associated with peritonitis. Adenosine levels in sites of inflammation were shown to increase and exhibit immunoregulatory effects. Our aim was to elucidate the regulatory role of adenosine during peritonitis and to test the involvement of peritoneal mesothelial cells (PMC) in adenosine regulation.
Rogachev, B., Ziv, N.Y., Mazar, J., Nakav, S., Chaimovitz, C., Zlotnik, M., Douvdevani, A.   +6 more
openaire   +2 more sources

SOX2 Promotes Invasion in Human Bladder Cancers through MMP2 Upregulation and FOXO1 Downregulation

International Journal of Molecular Sciences, 2022
SOX2, a member of the SRY-related HMG-box (SOX) family, is abnormally expressed in many tumors and associated with cancer stem cell-like properties. Previous reports have shown that SOX2 is a biomarker for cancer stem cells in human bladder cancer (BC), and our most recent study has indicated that the inhibition of SOX2 by anticancer compound ChlA-F ...
Qipeng Xie, Xiaohui Hua, Chao Huang, Xin Liao, Zhongxian Tian, Jiheng Xu, Yunping Zhao, Guosong Jiang, Haishan Huang, Chuanshu Huang   +9 more
openaire   +2 more sources

Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2020
Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang, Wei Zhang, Weiduo Hou, Weiduo Hou, Mo Chen, Erman Chen, Erman Chen, Deting Xue, Deting Xue, Chenyi Ye, Chenyi Ye, Weixu Li, Weixu Li, Zhijun Pan, Zhijun Pan   +14 more
doaj   +1 more source

Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Experimental and Molecular Medicine, 2023
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood.
Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Han   +8 more
doaj   +1 more source

Chlorogenic Acid Ameliorates Liver Function in Association with Bax Downregulation, P53 Downregulation and Bcl-2 Upregulation in Diabetic Wistar Rat [PDF]

BIO Web of Conferences, 2022
Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions in the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive apoptosis leads to liver dysfunction.
Setyaningsih Mayang, Meliala Andreanyta, Cempaka Rita, Arfian Nur   +3 more
doaj   +1 more source

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase

Biomedicines, 2021
To elucidate the effects of switching a PGF2α agonist, bimatoprost acid (BIM-A), to an EP2 agonist (Omidenepag—OMD; butaprost—Buta) or reversing the switching on adipose tissue, two-dimensional (2D) and three-dimensional (3D) cultures of 3T3-L1 cells ...
Yosuke Ida, Masato Furuhashi, Megumi Watanabe, Araya Umetsu, Fumihito Hikage, Hiroshi Ohguro   +5 more
doaj   +1 more source