Results 51 to 60 of about 462,684 (373)
microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ [PDF]
Journal of Translational Medicine, 2020 Abstract Background As a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. However, its role in prostate cancer is not clearly defined. Therefore, the aim of this study is to explore the effects and the specific mechanism of PES1 in prostate cancer ...
Yan Wang +6 more
openaire +4 more sources
Differential expression of microRNAs in mouse liver under aberrant energy metabolic status[S]
Journal of Lipid Research, 2009 Despite years of effort, exact pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains obscure. To gain an insight into the regulatory roles of microRNAs (miRNAs) in aberrant energy metabolic status and pathogenesis of NAFLD, we analyzed the ...
Shengjie Li +8 more
doaj +1 more source
Molecules, 2021 Rhodiolacrenulata (Hook.f. & Thomson) H.Ohba is an alpine medicinal plant that can survive in extreme high altitude environments. However, its changes to extreme high altitude are not yet clear.
Tingting Dong +3 more
doaj +1 more source
OncoTargets and Therapy, 2014 Background CD99 is involved in the intracellular transport of human leukocyte antigen class II (HLA-II) protein. The aim of this study was to clarify the clinical value of CD99 and HLA-II expression in primary osteosarcoma. Methods One hundred and thirty
Quan Zhou +4 more
semanticscholar +1 more source
Tumor Biology, 2014 Nucleostemin (NS) is a nucleolar protein involved in stem cell (SC) self-renewal by controlling cell cycle progression. In addition to SCs, NS is also expressed in some highly proliferating cells including several adult stem cells and cancer cell lines.
Ali Derakhshani +2 more
openaire +3 more sources
PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression [PDF]
, 2015 To overcome cancer cells resistance to pharmacological therapy, the development of new therapeutic approaches becomes urgent. For this purpose, the use of poly(ADP-ribose) polymerase (PARP) inhibitors in combination with other cytotoxic agents could ...
CAIAFA, Paola +11 more
core +2 more sources
Upregulation of inflammatory genes and downregulation of sclerostin are key elements for fracture healing [PDF]
Journal of Translational Medicine, 2010 Methods Fifty-six patients submitted to hip replacement surgery after a low-energy hip fracture were enrolled in this study. The patients were stratified according to the time interval between fracture and surgery: bone collected within 3 days after fracture (n=13); between the 4 and 7 day (n=33); and after one week from the fracture (n=10 ...
Jacinto Monteiro +10 more
openaire +3 more sources
Manipulation of Cannabinoid Biosynthesis via Transient RNAi Expression
Frontiers in Plant Science, 2021 Cannabis sativa L. produces unique phytocannabinoids, which are used for their pharmaceutical benefits. To date, there are no reports of in vivo engineering targeting the cannabinoid biosynthesis genes to greater elucidate the role each of these genes ...
Lennon Matchett-Oates +5 more
doaj +1 more source
Cell Death and Disease, 2014 Although ABT-737, a small-molecule Bcl-2/Bcl-xL inhibitor, has recently emerged as a novel cancer therapeutic agent, ABT-737-induced apoptosis is often blocked in several types of cancer cells with elevated expression of Mcl-1. Cafestol, one of the major
S. Woo +6 more
semanticscholar +1 more source
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda +5 more
core +1 more source