Results 51 to 60 of about 453,301 (335)

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity [PDF]

Diabetologia, 2012
Sirtuin-1 (SIRT1) is a potential therapeutic target to combat insulin resistance and type 2 diabetes. This study aims to identify a microRNA (miRNA) targeting SIRT1 to regulate hepatic insulin sensitivity.Luciferase assay combined with mutation and immunoblotting was used to screen and verify the bioinformatically predicted miRNAs.
B, Zhou, C, Li, W, Qi, Y, Zhang, F, Zhang, J X, Wu, Y N, Hu, D M, Wu, Y, Liu, T T, Yan, Q, Jing, M F, Liu, Q W, Zhai   +12 more
openaire   +2 more sources

Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

Regenerative Therapy
Background: This study investigated the molecular mechanism by which the combination of platelet-rich plasma (PRP) and isometric contraction of the quadriceps (ICQ) intervention regulates autophagy in chondrocytes to prevent and treat knee osteoarthritis
Liang Cheng, Shuwan Chang, Yajun Tan, Benxiang He   +3 more
doaj   +1 more source

MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma

Journal of Pharmacological Sciences, 2010
.: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of experimental ...
Yoshihiko Chiba, Miwa Misawa
doaj   +1 more source

Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet

Frontiers in Genetics, 2020
Manganese (Mn), primarily acquired through diet, is required for brain function and development. Epidemiological studies have found an association between both low and high levels of Mn and impaired neurodevelopment in children.
Young Ah Seo, Eun-Kyung Choi, Luisa Aring, Molly Paschall, Shigeki Iwase   +4 more
doaj   +1 more source

Nictaba homologs from Arabidopsis thaliana are involved in plant stress responses [PDF]

, 2018
Plants are constantly exposed to a wide range of environmental stresses, but evolved complicated adaptive and defense mechanisms which allow them to survive in unfavorable conditions.
Eggermont, Lore, Stefanowicz, Karolina, Van Damme, Els   +2 more
core   +3 more sources

The role of ischemic preconditioning in gene expression related to inflammation in a rat model of intestinal ischemia-reperfusion injury [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning (IPC).
Celina Teresa Castelo Branco Couto de Miranda, Djalma José Fagundes, Edinaldo de Miranda, Ricardo Santos Simões, Murched Omar Taha   +4 more
doaj   +1 more source

Genetic alterations of CDX1, CYLD and CDKN2B genes in CRC

Journal of Current Oncology and Medical Sciences, 2021
Introduction: Colorectal cancer (CRC) is the third most frequent type of cancer in the world. In this explanation, genetic variation is associated in all cancers, particularly CRC, and modifications of numerous genes, such as CDX1, CYLD, and CDKN2B, are ...
Seyed Mohammad Taghi Hamidian, Rezvan Azadi, Pooya Rostami , Farnaz Azar Shabe , Zeynab Khazaee Kohparc   +4 more
doaj  

Long noncoding RNA HOTTIP promotes the metastatic potential of ovarian cancer through the regulation of the miR‐615‐3p/SMARCE1 pathway

Kaohsiung Journal of Medical Sciences, 2020
Upregulation of lncRNA HOXA transcript at the distal tip (HOTTIP) plays important roles in cancer progression. Nevertheless, its functions in the growth and metastasis of ovarian carcinoma are unknown.
Hong Wu, Hong‐Yan Wei, Qian‐Qian Chen   +2 more
doaj   +1 more source

Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. [PDF]

PLoS ONE, 2013
Nogo Receptor 1 (NgR1) mRNA is downregulated in hippocampal and cortical regions by increased neuronal activity such as a kainic acid challenge or by exposing rats to running wheels.
Tobias E Karlsson, Josefin Koczy, Stefan Brené, Lars Olson, Anna Josephson   +4 more
doaj   +1 more source

Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma

Tumor Biology, 2014
Nucleostemin (NS) is a nucleolar protein involved in stem cell (SC) self-renewal by controlling cell cycle progression. In addition to SCs, NS is also expressed in some highly proliferating cells including several adult stem cells and cancer cell lines.
Malek Hossein, Asadi, Ali, Derakhshani, Seyed Javad, Mowla   +2 more
openaire   +2 more sources