Results 61 to 70 of about 453,301 (335)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
International Journal of Inflammation, 2014 Live combined Bacillus subtilis and Enterococcus faecium ameliorate murine experimental colitis by immunosuppression manifested by downregulation of TLRs, macrophages, Th1, and Th2 but upregulation of Tregs.
S. Chen +7 more
doaj +1 more source
LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. [PDF]
PLoS ONE, 2016 The pathology of proliferative vitreoretinopathy and proliferative diabetic retinopathy is linked to proliferation, migration, and adhesion of the retinal pigment epithelium.
Qiang Hou +10 more
doaj +1 more source
Heliyon, 2021 Aims: This study aimed to explore the potential protective effect of α-lipoic acid on busulfan-induced pulmonary fibrosis in rats. Main methods: Eighteen adult male rats were divided into 3 groups; control, busulfan, and busulfan plus α-lipoic acid ...
Mona G. Elhadidy +6 more
doaj +1 more source
Potential immunosuppressive effects of Escherichia coli O157:H7 experimental infection on the bovine host [PDF]
, 2016 Background: Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7 are frequently detected in bovine faecal samples at slaughter. Cattle do not show clinical symptoms upon infection, but for humans the consequences after consuming contaminated ...
Cox, Eric +4 more
core +1 more source
Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion
Molecular Medicine Reports, 2019 A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS‑7) has been revealed to serve an important role in inflammation‑associated diseases. However, the role of ADAMTS‑7 in spontaneous abortion (SA) remains unclear. In the present study, human and mouse decidual tissues were used to detect the expression of ADAMTS‑7 and cartilage ...
Mu, Yang +4 more
openaire +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
HeliyonBackground: Intestinal bacteria significantly contribute to the metabolism of intestinal epithelial tissues. As the occurrence and development of radiation enteritis (RE) depend on the “co-metabolism” microenvironment formed by the host and intestinal ...
Chen-ying Ma, Jing Zhao, Ju-ying Zhou
doaj +1 more source
Perceived Maternal Invalidation and Drinking Behavior: The Role of Action Control [PDF]
, 2018 Alcohol use disorder is one of the most prevalent disorders worldwide. As such, researchers have examined factors contributing to alcohol use. Perception of emotional experiences in childhood as invalidating by parents is one factor that has been found ...
Warner, Elise Ann
core +2 more sources
microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]
, 2017 Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke +12 more
core +1 more source