Results 81 to 90 of about 378,928 (303)

Downregulation of microRNA-497 is associated with upregulation of synuclein γ in patients with osteosarcoma

Experimental and Therapeutic Medicine, 2016
The present study aimed to investigate the effects of microRNA (miRNA/miR)-497 expression levels on the expression levels of synuclein γ (SNCG) in serum samples, as well as osteosarcoma and lung-metastatic tissue samples, from patients with osteosarcoma. Between December 2010 and August 2013, fasting peripheral blood was collected from 36 patients with
Liang, Wang, Hongwei, Gao, Ningji, Gong, Mingzhi, Gong   +3 more
openaire   +3 more sources

LncRNA IUR downregulates ZEB1 by upregulating miR-200 to inhibit prostate carcinoma [PDF]

Physiological Genomics, 2019
We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR.
Lingjun, Sun, Taowei, Chen, Tao, Li, Jianda, Yu   +3 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

Nature Communications
Parkinson disease (PD) is a heterogeneous syndrome. There is a need for biology-driven subtyping to inform specific therapeutic strategies. In a two-center study with de novo and established PD cohorts, we use vesicular acetylcholine transporter ligand ...
Nicolaas I. Bohnen, Stiven Roytman, Sygrid van der Zee, Giulia Carli, Fotini Michalakis, Austin Luker, Sofie Slingerland, Kirk A. Frey, Peter J. H. Scott, Robert A. Koeppe, Teus van Laar, Roger L. Albin, Prabesh Kanel   +12 more
doaj   +1 more source

LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. [PDF]

PLoS ONE, 2016
The pathology of proliferative vitreoretinopathy and proliferative diabetic retinopathy is linked to proliferation, migration, and adhesion of the retinal pigment epithelium.
Qiang Hou, Linglin Zhou, Jiajia Tang, Nan Ma, Ancong Xu, Jiang Tang, Dandan Zheng, Xiaogang Chen, Feng Chen, Xiang Da Dong, LiLi Tu   +10 more
doaj   +1 more source

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Heliyon, 2021
Aims: This study aimed to explore the potential protective effect of α-lipoic acid on busulfan-induced pulmonary fibrosis in rats. Main methods: Eighteen adult male rats were divided into 3 groups; control, busulfan, and busulfan plus α-lipoic acid ...
Mona G. Elhadidy, Ahlam Elmasry, Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Shereen Hamed, Mahmoud M. Elalfy, Mohammed R. Rabei   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma

, 2011
Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. p27Kip1 (p27) is one of the major cyclin‐CDK regulators in the G1 phase.
Sreelatha Gopinath, Rama Rao Malla, Jasti S. Rao, Christopher S. Gondi, Dzung H. Dinh, Kiranmai Alapati, Sanjeeva Mohanam   +6 more
core   +1 more source