Results 21 to 30 of about 413,339 (385)

Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review

Molecules, 2022
The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide.
Sijongesonke Peter, S. Alven, Rejoice B. Maseko, B. Aderibigbe   +3 more
semanticscholar   +1 more source

Modulation of STAT3 signaling, cell redox defenses and cell cycle checkpoints by β-caryophyllene in cholangiocarcinoma cells: possible mechanisms accounting for doxorubicin chemosensitization and chemoprevention [PDF]

, 2020
Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes.
Di Giacomo, Silvia, Di Sotto, Antonella, Eufemi, Margherita, Gulli, Marco, Macone, Alberto, Mammola, Caterina Loredana, Mancinelli, Romina, Mazzanti, Gabriela, Rubini, Elisabetta   +8 more
core   +1 more source

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy.

Circulation Research, 2020
Anthracycline-based chemotherapy can result in the development of a cumulative and progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed anthracyclines in the United States due to its broad spectrum of therapeutic ...
K. Wallace, V. Sardão, P. Oliveira
semanticscholar   +1 more source

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma.

ACS Nano, 2020
Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is among the deadliest malignancies. Doxorubicin widely used in transarterial chemotherapy in HCC can induce immunogenic cell death (ICD), but the resulting immunogenicity is
Zhuo Yu, Jianfeng Guo, Mengying Hu, Yueqiu Gao, Leaf Huang   +4 more
semanticscholar   +1 more source

Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View From the Perspective of the Pathophysiologist and the Clinician

Frontiers in Pharmacology, 2021
Today the pharmacological possibilities of treating cancer are expanding and as a result, life expectancy is increasing against the background of chemotherapy and supportive treatment.
E. Podyacheva, E. Kushnareva, A. A. Karpov, Y. Toropova   +3 more
semanticscholar   +1 more source

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin, Bartunek, Jozef, Beerens, Manu, Bloch, Donald B, Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Caluwe, Ellen, Gillijns, Hilde, Janssens, Stefan P, Nathan, Daniel I, Scherrer-Crosbie, Marielle, Swinnen, Melissa, Tainsh, Robert E, Vandenwijngaert, Sara, Walravens, Ann-Sophie   +15 more
core   +1 more source

Doxorubicin Selectively Inhibits Brain versus Atrial Natriuretic Peptide Gene Expression in Cultured Neonatal Rat Myocytes [PDF]

, 1999
Doxorubicin is an antineoplastic agent with significant cardiotoxicity. We examined the effects of this agent on the expression of the natriuretic peptide (NP) genes in cultured neonatal rat atrial myocytes.
Chen, Songcang, Garami, Miklós, Gardner, D. G.   +2 more
core   +1 more source

Fasting Reduces the Incidence of Delayed-Type Vomiting Associated with Doxorubicin Treatment in Dogs with Lymphoma. [PDF]

, 2014
Fasting reduces gastrointestinal cellular proliferation rates through G1 cycle blockade and can promote cellular protection of normal but not cancer cells through altered cell signaling including down-regulation of insulin-like growth factor 1 (IGF-1 ...
Guerrero, Teri A, Kass, Philip H, O'Brien, Danielle, Rebhun, Robert B, Rodriguez, Carlos O, Sein, Kristen D, Skorupski, Katherine A, Withers, Sita S   +7 more
core   +1 more source

Lipid Emulsion Inhibits the Late Apoptosis/Cardiotoxicity Induced by Doxorubicin in Rat Cardiomyoblasts

Cells, 2018
This study aimed to examine the effect of lipid emulsion on the cardiotoxicity induced by doxorubicin in H9c2 rat cardiomyoblasts and elucidates the associated cellular mechanism.
Raghavendra Baregundi Subbarao, Seong-Ho Ok, Soo Hee Lee, Dawon Kang, Eun-Jin Kim, Ji-Yoon Kim, Ju-Tae Sohn   +6 more
doaj   +1 more source

Randomized phase II study of the PDGFRα antibody olaratumab plus liposomal doxorubicin versus liposomal doxorubicin alone in patients with platinum-refractory or platinum-resistant advanced ovarian cancer

BMC Cancer, 2018
Background Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian cancer outcomes.
William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir, Robert Ilaria   +6 more
doaj   +1 more source