Results 51 to 60 of about 397,699 (411)
Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells
Cancer Cell International, 2018 Background Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transporters.
Shao-hsuan Wen +4 more
doaj +1 more source
Molecular Medicine, 2021 Background Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activation of inflammatory NF-κB ...
Haijun Zhao +3 more
doaj +1 more source
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]
, 2017 BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen +13 more
core +2 more sources
Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin [PDF]
Journal of Translational Medicine 2014, 12:227, 2016 We explored how the knowledge translation and innovation processes are structured when they result in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH ...
arxiv +1 more source
TP53 alteration determines the combinational cytotoxic effect of doxorubicin and an antioxidant NAC
Tumor Biology, 2017 The anticancer effect of doxorubicin is closely related to the generation of reactive oxygen species. On the contrary, doxorubicin-induced reactive oxygen species induces heart failure, a critical side effect of doxorubicin.
Yun Sun Lee +5 more
doaj +1 more source
Pharmaceutics, 2023 Doxorubicin is a potent chemotherapeutic drug; however, its clinical application has been limited due to its cardiotoxicity. One of the major mechanisms of doxorubicin-induced cardiotoxicity is the induction of oxidative stress.
Tanawat Attachaipanich +2 more
doaj +1 more source
BMC Cancer, 2012 Background Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cancer patients.
Heibein Allan D +4 more
doaj +1 more source
Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy [PDF]
, 2017 Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis.
A C Belkina +7 more
core +1 more source
Oxidative Medicine and Cellular Longevity, 2021 Doxorubicin is a drug that belongs to the anthracycline antibiotics. Nephrotoxicity is one of the serious side effects of doxorubicin treatment. Crocin, which is one of the most bioactive components of saffron, has antioxidant, anti-inflammatory, and ...
M. Hussain +5 more
semanticscholar +1 more source
Magnetic biophysical characterization of biomimetic polyeth-ylenimine-coated nanoparticles on in vitro silico model [PDF]
arXiv, 2022 Understanding the biophysical and magnetic interactions of nanoparticles (NPs) with cell mem-branes is critical for developing effective nanocarrier systems for drug delivery applications and targeted nanophysics applications. Recent discoveries in nanomedicine can be used to test an in vitro system that reproduce a similar tumor model.
arxiv