Results 61 to 70 of about 1,539,229 (306)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Nuclear Energy and Technology, 2015 The paper presents an experimental study into the thermal-hydraulic performance of the VK-300 reactor based on a model of a single draft tube at a pressure of 3.4MPa, various flow rates and the model inlet relative enthalpies of –0.05 to 0.2.
N.P. Serdun +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Effect of Fins on the Internal Flow Characteristics in the Draft Tube of a Francis Turbine Model
Energies, 2020 Undesirable flow phenomena in Francis turbines are caused by pressure fluctuations induced under conditions of low flow rate; the resulting vortex ropes with precession in the draft tube (DT) can degrade performance and increase the instability of ...
Seung-Jun Kim +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hydrodynamics of a self-agitated draft tube airlift reactor [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2014 The main hydrodynamic characteristics of a novel-constructed, self-agitated draft tube airlift reactor (DT-ALR) were investigated. Ten impellers, driven only by the means of gas throughput and induced liquid circulation, were inserted in the ...
Tekić Miodrag N. +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CFD based draft tube hydraulic design optimization
IOP Conference Series: Earth and Environmental Science, 2014 The draft tube design of a hydraulic turbine, particularly in low to medium head applications, plays an important role in determining the efficiency and power characteristics of the overall machine, since an important proportion of the available energy, being in kinetic form leaving the runner, needs to be recovered by the draft tube into static head ...
J McNabb +4 more
openaire +1 more source
, 2020 A methodology to assess the performance of an elbow-type draft tube is outlined. This was achieved using Computational Fluid Dynamics (CFD) to evaluate the pressure recovery and mechanical energy losses along a draft tube design, while using open-source ...
S. Daniels +4 more
semanticscholar +1 more source