Results 81 to 90 of about 180,725 (290)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Tuning in: diasporas at the BBC World Service

open access: yes, 2011
This article looks at diaspora through the transformations of an established public service broadcaster, the BBC World Service in a fast changing landscape of global broadcasting, by considering some of the findings of the AHRC-funded Tuning In: Contact ...
Woodward, Kath
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Methodological issues in national-comparative research on cultural tastes : the case of cultural capital in the UK and Finland [PDF]

open access: yes, 2013
Drawing on two projects which develop the methodological model of Bourdieu’s Distinction in the UK and Finland, this paper explores the issues raised by the use of multiple correspondence analysis (MCA) and mixed methods in comparative work on cultural ...
Purhonen, Semi, Wright, David
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Author’s Epithet in A. Casona’s Dramas: Features of Functioning and Problem of Translation

open access: yesНаучный диалог, 2018
The article is devoted to art techniques most typical to A. Casona’s idiostyle - the author’s epithet - in the aspect of translation into Russian. The term “ author’s epithet ” means an unexpected, non-reproducible combination enriching the writer’s ...
V. V. Shchepalina
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

La Fedra di Seneca-Sanguineti: rilettura di una traduzione per la messinscena

open access: yesErga-Logoi, 2014
The purpose of this study is to fill a gap about Edoardo Sanguineti’s translations in the current bibliography. Despite the fact that Friedmar Apel’s method brings a sweeping change to research in the field of translation studies and many works about ...
Sara Bandiera
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

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