Results 41 to 50 of about 837,527 (297)

Numerical modelling of heat transfer in a tube furnace for steel wire annealing [PDF]

, 2012
In order to relieve stresses from cold drawing and to regain ductility, steel wires are annealed in furnaces under prolonged exposure to an appropriate temperature termed as ‘soaking’.
Baddage, S., Hasan, Reaz, Perera, Noel, Persson, Martin   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Numerical analysis to determine the impact of land subsidence on high-speed railway routes in Beijing, China [PDF]

Proceedings of the International Association of Hydrological Sciences, 2015
More than 10 high-speed railway routes with top speeds of 300 km h−1 are expected to be operational from Beijing by the year 2020. However, the safety of these routes is affected by the occurrence of land subsidence.
C. Ye, Y. Yang, Y. Yang, F. Tian, Y. Luo, Y. Luo, Y. Zhou, Y. Zhou   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Influence of interactive learning support system using augmented reality on 3D object drawing

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
The 3D pen is a tool that can output a melted resin from a pen tip to form a 3D object. In order to shape an object using a 3D pen, it is necessary to practice it and understand how to use it, and many beginners find it difficult to handle.
Masashi OKUBO, Yukari MIZUNO
doaj   +1 more source

A Sparse Stress Model

, 2016
Force-directed layout methods constitute the most common approach to draw general graphs. Among them, stress minimization produces layouts of comparatively high quality but also imposes comparatively high computational demands.
A Frick, C Walshaw, D Tunkelang, ER Gansner, ER Gansner, ER Gansner, H Meyerhenke, I Borg, J Barnes, JD Cohen, KM Hall, M Khoury, M Klimenta, P Drineas, P Gajer, R Sibson, RK Gabriel, S Hachul, SG Kobourov, TA Davis, TMJ Fruchterman, U Brandes, U Brandes, U Brandes, U Brandes, V de Silva, VE McGee, Y Hu   +27 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Optimization and finite element analysis of the drawing process for rolling linear guide slider [PDF]

Journal of Hebei University of Science and Technology
Aiming to address the issue of increased production costs caused by the five-pass cold drawing forming for the sliding block in the rolling linear guide pair in a factory in Hebei Province, this study investigated the influence of parameters such as die ...
Yan GAO, Runzheng WANG, Wang LI, Haikun MA, Honggang MO, Pengbiao HAN   +5 more
doaj   +1 more source

Mechanized fluid connector and assembly tool system with ball detents [PDF]

, 1991
A fluid connector system is disclosed which includes a modified plumbing union having a rotatable member for drawing said union into a fluid tight condition.
Smith, Steven A., Zentner, Ronald C.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source