Results 61 to 70 of about 2,435,567 (309)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effects of Equal Volume But Different Plyometric Jump Training Intensities on Components of Physical Fitness in Physically Active Young Males [PDF]

, 2019
An 8-week single-blind randomized controlled trial was conducted to compare the effects of separate programs of equal volume, but different intensity, plyometric jump training (PJT), on physical fitness in healthy adults.
Andrade, Argus, Asadi, Balsalobre-Fernandez, Behm, Brumitt, de Villarreal, Ebben, Ebben, Ebben, Flanagan, Granacher, Hopkins, Hopkins, Lees, Markovic, Peng, Piper, Pueo, Radnor, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Randell, Read, Ronnestad, Saez-Saez de Villarreal, Sáez de Villarreal, Taube, Thomas, Trecroci, Van Lieshout, Young   +37 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Drop tower impact rig to assess the effectiveness of suspension seat for small high-speed passenger craft

Brodogradnja
This work aims to design a drop tower impact rig to examine the effectiveness of suspension seats for small high-speed passenger crafts and to evaluate whether the designed suspension seat can effectively mitigate the slamming impact on passengers and ...
Faisal Ikram Bin Abd Samad, Mohd Yuzri Bin Mohd Yusop, Nik Mohd Ridzuan Bin Shaharuddin, Omar Bin Yaakob   +3 more
doaj   +1 more source

Intrusion Detection Using Mouse Dynamics

, 2018
Compared to other behavioural biometrics, mouse dynamics is a less explored area. General purpose data sets containing unrestricted mouse usage data are usually not available.
Antal, Margit, Egyed-Zsigmond, Elod
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Mechanical Characterization and Dual-Layer Discrete Element Modeling of Mactra veneriformis

Fishes
The discrete element model of Mactra veneriformis currently employs an oversimplified multi-sphere approach using EDEM’s Hertz–Mindlin model, assuming uniform shell–flesh mechanical properties. This study developed an advanced dual-layer flexible bonding
Bin Xu, Yazhou Yang, Hangqi Li, Guangcong Chen, Yizhi Chang, Feihong Guo, Hao Wu, Jixuan Zhao, Zijing Liu, Guochen Zhang, Xiuchen Li, Hanbing Zhang, Qian Zhang, Gang Mu   +13 more
doaj   +1 more source

B-52B/DTV (Drop Test Vehicle) flight test results: Drop test missions [PDF]

The NASA test airplane, B-52B-008, was a carrier for drop tests of the shuttle booster recovery parachute system. The purpose of the test support by Boeing was to monitor the vertical loads on the pylon hooks.
Doty, L. J.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source