Next-generation large-scale binary protein interaction network for Drosophila melanogaster
Nature Communications, 2023 Generating reference maps of interactome networks illuminates genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes.
Hong-Wen Tang +42 more
doaj +1 more source
Fluorescent protein tagging confirms the presence of ribosomal proteins atDrosophilapolytene chromosomes [PDF]
, 2013 \ud \ud Most ribosomal proteins (RPs) are stoichiometrically incorporated into ribosomal subunits and play essential roles in ribosome biogenesis and function.
Bischof +27 more
core +3 more sources
Identification and Investigation of Postsynaptic Density Homologs
Bioinformatics and Biology Insights, 2008 AMPA receptors are responsible for fast excitatory transmission in the CNS and the trafficking of these receptors has been implicated in LTP and learning and memory. These receptors reside in the postsynaptic density, a network of proteins that links the
Faith L.W. Liebl, David E. Featherstone
doaj +1 more source
Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila
Journal of Developmental Biology, 2023 The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in Drosophila, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson ...
Annely Brandt +3 more
doaj +1 more source
echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases [PDF]
, 2007 Background: Programmed cell death is used to remove excess cells between ommatidia in the Drosophila pupal retina. This death is required to establish the crystalline, hexagonal packing of ommatidia that characterizes the adult fly eye.
Bosdet, Ian +5 more
core +4 more sources
Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains
Genome Research, 2012 Several multiprotein DNA complexes capable of insulator activity have been identified in Drosophila melanogaster, yet only CTCF, a highly conserved zinc finger protein, and the transcription factor TFIIIC have been shown to function in mammals.
Kevin Van Bortle +5 more
semanticscholar +1 more source
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]
, 2011 The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB +3 more
core +2 more sources
BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila
Nature Communications, 2019 The BEN-solo proteins—including Insensitive (Insv), Elba1 and Elba2—function in both transcriptional repression and chromatin insulation. Here, the authors investigate the role of these proteins in Drosophila embryos, finding that ELBA and Insv function ...
Malin Ueberschär +8 more
doaj +1 more source
Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]
, 2015 Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A +3 more
core +1 more source
The GAGA Protein of Drosophila is Phosphorylated by CK2
Journal of Molecular Biology, 2005 The GAGA factor of Drosophila is a sequence-specific DNA-binding protein that contributes to multiple processes from the regulation of gene expression to the structural organisation of heterochromatin and chromatin remodelling. GAGA is known to interact with various other proteins (tramtrack, pipsqueak, batman and dSAP18) and protein complexes (PRC1 ...
Bonet-Costa, Carles +5 more
openaire +4 more sources