Results 61 to 70 of about 1,147,985 (197)

Drug–drug interaction analysis: Antituberculosis drugs versus antiretroviral drugs

Biomedical and Biotechnology Research Journal, 2019
Background: Human immunodeficiency virus (HIV) infection is an important public health globally. An important concomitant medical disorder among HIV-infected patients is tuberculosis. The management of concurrent infection between HIV and tuberculosis is
Won Sriwijitalai, Viroj Wiwanitkit
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

DDIGIP: predicting drug-drug interactions based on Gaussian interaction profile kernels

BMC Bioinformatics, 2019
Background A drug-drug interaction (DDI) is defined as a drug effect modified by another drug, which is very common in treating complex diseases such as cancer.
Cheng Yan, Guihua Duan, Yi Pan, Fang-Xiang Wu, Jianxin Wang   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Mechanisms and the clinical relevance of complex drug–drug interactions

Clinical Pharmacology: Advances and Applications, 2018
Arthur G Roberts, Morgan E Gibbs Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA Abstract: As a result of an increasing aging population, the number of individuals taking multiple medications simultaneously has grown ...
Roberts AG, Gibbs ME
doaj  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Preclinical Pharmacokinetics, ADME, and Drug-Drug Interaction Evaluation of S024, a Novel p38/MK2 Inhibitor for Rheumatoid Arthritis

Drug Design, Development and Therapy
Qianlei Ye,1,2,* Wei Xing,2,* Xuefeng Hu,2 Wenjuan Liu,2 Jigang Wu,2 Hailan Huang,2 Ying Xiao,2 Yanjun Hong1 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Shenzhen Salubris ...
Ye Q, Xing W, Hu X, Liu W, Wu J, Huang H, Xiao Y, Hong Y   +7 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Drug-DNA interaction protocols

European Journal of Histochemistry, 2010
In a paper published by Jurgen Drews on the march 17, 2000 issue of Science a figure reporting molecular targets of drug therapy, classified according to biochemical criteria, showed that only 2% of drugs were directed to DNA.
Stefano Govoni
doaj   +1 more source