Results 61 to 70 of about 2,208,548 (262)

Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing

Pharmaceutics
Objectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology.
Hye Jin Park, Dong Wuk Kim
doaj   +1 more source

Announcing the 2015 Viruses Young Investigator Prize and Graduate Student/Postdoctoral Fellow Travel Awards

Viruses, 2015
With the goal of recognizing outstanding contributions to the field of virology by early-career investigators, last year Viruses accepted nominations for a 2015 Young Investigator Prize in Virology. The target age was set at 40 and under.
Eric O. Freed
doaj   +1 more source

Trends of Analytical Research on Drug-drug Interaction [PDF]

, 2014
薬物-薬物相互作用は薬物治療において非常に重要な事項である｡薬物はそれ自身で副作用を生じうるが､複数の薬物を併用することで予期しない重篤な有害事象を引き起こすこともある｡この意味で､薬物-薬物相互作用に関する分析化学的な研究が非常に重要であり､薬物治療の手助けとなる｡本総説では､薬物-薬物相互作用の分析化学的研究の最近の動向について､特に微小透析技術に基づいた方法について記述する｡Drug-drug interaction is very important matter for the ...
Kenichiro NAKASHIMA, Rie IKEDA, Seitaro KAMIYA, Yoshihito OHBA, 中島 憲一郎, 大庭 義史, 池田 理恵, 神谷 誠太郎   +7 more
core   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

Outcome-based pricing for new pharmaceuticals via rebates [PDF]

, 2020
The price of new brand-name prescription drugs has been rising fast in the United States. For example, the Amgen cholesterol drug Repatha had an initial list price of $14,523 per year.
Adida, E
core  

Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate. [PDF]

, 2013
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
Ansari, Mahvash, Hussain, Talib, Khan, Ikram Ullah, Ranjha, Nazar Muhammad, Shahzad, Yasser   +4 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Anticancer Activity of Paclitaxel-Loaded Mesoporous Silica Nanoparticles in B16F10 Melanoma-Bearing Mice

Pharmaceutics
Background/Objectives: Paclitaxel (PTX) faces clinical limitations in melanoma treatment due to poor solubility, P-glycoprotein (P-gp)-mediated efflux, and systemic toxicity.
Jihoon Lee, Jung Mo Kim, Yeon-Ju Baek, Hyojeung Kang, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]

, 2012
Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T., Subramaniam, G., Lee, J., Loh, H.M., Leung, P.H.H.   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source