Results 71 to 80 of about 2,208,548 (262)

The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations [PDF]

, 2005
This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most ...
García-Alonso, M. D. C., Mariñoso, B. G.   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Potensi Interaksi Obat Pada Pasien Gangguan Ginjal Kronis di Instalasi Rawat Inap RSUD Dr. Moewardi Tahun 2014 [PDF]

, 2016
Chronic kidney disease (CKD) is a condition which characterized by a gradual loss of kidney function accompanied by manifestations of kidney pathology abnormality for at least three months. Patients with chronic kidney disease who have some complications
Khasanah, Rizqi Nurul
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Drug interaction: Omeprazole and Phenprocoumon [PDF]

, 2001
Background Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious
Christa Enderle, Willi Müller, Ulrich Grass, MD Freedman, CS Landefeld, T Andersson, UA Meyer, ALM Kerremans, SA Wrigton, DJ Newton, J-W Ko, M He, T Andersson, M Chang, S Ahmad, B Garcia   +15 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Drug Overdose Rates Are Highest in Places With the Most Economic and Family Distress [PDF]

, 2018
In this brief, author Shannon Monnat examines county-level mortality data from the U.S. Centers for Disease Control and Prevention, pooled for 2006–2015, to gain insight into the U.S. drug overdose problem.
Monnat, Shannon M.
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Kajian Potensi Interaksi Obat Antihipertensi Pada Pasien Hipertensi Primer Di Instalasi Rawat Jalan RSUD Luwuk Periode Januari – Maret 2016 [PDF]

, 2017
KAJIAN POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI PRIMER DI INSTALASI RAWAT JALAN RSUD LUWUK PERIODE JANUARI – MARET 2016 Yesia Stevani Mahamudu1), Gayatri Citraningtyas1), Henki Rotinsulu1)1)Program studi farmasi FMIPA UNSRAT Manado ...
Mahamudu, Y. S. (Yesia)
core   +2 more sources