Results 71 to 80 of about 2,190,373 (263)

Anticancer Activity of Paclitaxel-Loaded Mesoporous Silica Nanoparticles in B16F10 Melanoma-Bearing Mice

Pharmaceutics
Background/Objectives: Paclitaxel (PTX) faces clinical limitations in melanoma treatment due to poor solubility, P-glycoprotein (P-gp)-mediated efflux, and systemic toxicity.
Jihoon Lee, Jung Mo Kim, Yeon-Ju Baek, Hyojeung Kang, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Potensi Interaksi Obat Pada Pasien Gangguan Ginjal Kronis di Instalasi Rawat Inap RSUD Dr. Moewardi Tahun 2014 [PDF]

, 2016
Chronic kidney disease (CKD) is a condition which characterized by a gradual loss of kidney function accompanied by manifestations of kidney pathology abnormality for at least three months. Patients with chronic kidney disease who have some complications
Khasanah, Rizqi Nurul
core  

Kajian Potensi Interaksi Obat Antihipertensi Pada Pasien Hipertensi Primer Di Instalasi Rawat Jalan RSUD Luwuk Periode Januari – Maret 2016 [PDF]

, 2017
KAJIAN POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI PRIMER DI INSTALASI RAWAT JALAN RSUD LUWUK PERIODE JANUARI – MARET 2016 Yesia Stevani Mahamudu1), Gayatri Citraningtyas1), Henki Rotinsulu1)1)Program studi farmasi FMIPA UNSRAT Manado ...
Mahamudu, Y. S. (Yesia)
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Systematic Exploration of Synergistic Drug Pairs [PDF]

, 2013
Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways (‘specific synergy’).
Andrews, Brenda J, Baryshnikova, Anastasia, Boone, Charles, Chua, Hon Nian, Cokol, Murat, Costanzo, Michael, Giaever, Guri, Mutlu, Beste, Myers, Chad L, Nergiz, Mehmet E, Nislow, Corey, Roth, Frederick Phillip, Suzuki, Yo, Tasan, Murat, Weinstein, Zohar B   +14 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

Clinical and Translational Science, 2023
Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10–16 million people use kratom. Kratom‐
Xiaotong Li, Patrick Ndungu, Sanya B. Taneja, Maryann R. Chapin, Susan B. Egbert, Krishi Akenapalli, Mary F. Paine, Sandra L. Kane‐Gill, Richard D. Boyce   +8 more
doaj   +1 more source

The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations [PDF]

, 2005
This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most ...
García-Alonso, M. D. C., Mariñoso, B. G.   +1 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source