Results 111 to 120 of about 1,137,228 (316)

Medication Prescribing Patterns for Chronic Kidney Diseases: Analysis of Drug-Dose Adjustments, Polypharmacy, and Drug Interactions

Background: Multiple drug prescriptions in chronic kidney disease (CKD) escalate metabolic buildup, nephrotoxicity, and end stage kidney disease progression.
Ikilas Moldaliyev, Rita Assabayeva, Meruyert Madikenova, Dmitriy Sychev, Ali Issayev, Dmitriy Syssoyev, Aizat Seidakhmetova, Ainur Assan, Zakira Kerimbayeva, Abduzhappar Gaipov   +9 more
core   +1 more source

Evaluation Of Clinically Important Drug Interactions Involving Angiotensin-Converting Enzyme Inhibitors Among Cardiac Patients [QP609.A53 F219 2008 f rb]. [PDF]

, 2008
Perencat penukar enzim angiotensin (ACEIs) telah digunakan secara meluas untuk merawat hipertensi dan penyakit kardiovaskular yang lain. Interaksi ubat-ACEI adalah merupakan masalah kesihatan yang signifikan dan perlu penyelidikan lanjut.
Amir Abdelkarim Farag, Omalhassan
core  

NSAIDs and contraceptives: critical thinking on a harmful drug interaction [PDF]

, 2023
Kamran Abbasi
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Peer Review #1 of "Developing a machine learning model to identify protein–protein interaction hotspots to facilitate drug discovery (v0.2)"

, 2020

openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Drug-related problems with special emphasis on drug : drug interactions

, 2009
The aim of this thesis was to address some aspects of drug related problems with special regard to drug-drug interactions.In paper I we aimed to describe the scenario and frequency of drug-related problems (DRPs) in in-patients and to determine whether a
Buster Mannheimer (442516)
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exploratory Evaluation of Solanidine as an Endogenous Marker for CYP2D6‐Mediated Drug–Drug–Gene Interactions of Venlafaxine in Koreans

Clinical and Translational Science
CYP2D6‐mediated drug–drug–gene interactions (DDGIs) are known to influence the pharmacokinetics of venlafaxine and its metabolism to O‐desmethylvenlafaxine.
Sungyeun Bae, Ga‐Yeong Lee, Eunsol Yang, Woori Chae, Kyung‐Sang Yu, Joo‐Youn Cho, Anhye Kim, Namyi Gu, SeungHwan Lee   +8 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source