Results 201 to 210 of about 1,137,228 (316)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Drug Safety in Hospitalized Diabetes Patients: A Retrospective Analysis of Predictors and Clinical Relevance of Potential Drug-Drug Interactions. [PDF]

Healthcare (Basel)
Khan MA, Syafhan NF, Noor S, Alshammari MS, Alotaibi M, Alrohily W, Alanazi AH, Alsubhi WA, Al Shammari L, Imran MR, Ahmad A.   +10 more
europepmc   +1 more source

Drug-drug interaction between TAS-303 and simvastatin/midazolam in healthy subjects

, 2018
Yuji Kumagai, Tomoe Fujita, Masako Aso, Hideki Amano, Yoshinobu Sasaki, Masaki Kawai, Toru Takenaka, Makoto Nagaoka, Koichiro Hoashi   +8 more
openalex   +2 more sources

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development [PDF]

, 2011
Sandhya Girish, Steven W. Martin, Mark Peterson, Lei K. Zhang, Hong Zhao, Joseph P. Balthasar, Raymond Evers, Honghui Zhou, Min Zhu, Lewis J. Klunk, Chao Han, Eva Gil Berglund, Shiew‐Mei Huang, Amita Joshi   +13 more
openalex   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Closing the loop: human-augmented, mechanistically enhanced AI for proactive management of drug-drug interactions. [PDF]

Front Pharmacol
Spanakis M, De Pauw A, Brumer M, Symvoulakis EK, De Loof H.   +4 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Polypharmacy in Elderly Patients Receiving First-Line Treatment for Pancreatic Adenocarcinoma: Analysis of Potential Drug-Drug Interactions and Outcome. [PDF]

Oncol Res
Vecchia S, Chinelli R, Orcesi A, Citterio C, Riva A, Orlandi E.   +5 more
europepmc   +1 more source

Automated extraction of food-drug interactions from scientific articles

, 2018
Tsanta Randriatsitohaina
openalex   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source