Results 131 to 140 of about 7,431,159 (264)

Genetic insights into the shared molecular mechanisms of Crohn’s disease and breast cancer: a Mendelian randomization and deep learning approach

Discover Oncology
The objective of this study was to explore the potential genetic link between Crohn’s disease and breast cancer, with a focus on identifying druggable genes that may have therapeutic relevance.
Zhuang Zhuang Wang, Ju Lin Yang, Zong Yao Zhang, Pei Bin Wang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Use of artemether-lumefantrine in the treatment of asymptomatic-malaria infection in HIV-positive and HIVnegative Nigerian adults. [PDF]

Malaria /HIV co-infection is a major challenge to public health in developing countries and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both HIV and Plasmodium ...
Chijioke-Nwauche, IN
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Gene Expression Modifications by Temperature-Toxicants Interactions in Caenorhabditis elegans [PDF]

, 2011
Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses.
Vinuela Rodriguez, A., Kammenga Jan E., Joost A. G. Riksen, Riksen Joost A. G., Ana Viñuela, L Basten Snoek, Viñuela Ana, Jan E. Kammenga, Joost A G Riksen, Kammenga, J.E., Snoek, L.B., L. Basten Snoek, Jan E Kammenga, Snoek L. Basten, Riksen, J.A.G.   +14 more
core   +1 more source

Integrated edge information and pathway topology for drug-disease associations

iScience
Summary: Drug repurposing is a promising approach to find new therapeutic indications for approved drugs. Many computational approaches have been proposed to prioritize candidate anticancer drugs by gene or pathway level.
Xianbin Li, Xiangzhen Zan, Tao Liu, Xiwei Dong, Haqi Zhang, Qizhang Li, Zhenshen Bao, Jie Lin   +7 more
doaj   +1 more source

Identifying drug-gene interactions from CRISPR knockout screens with drugZ

bioRxiv, 2017
Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of small molecules. This knowledge provides insights into drug mechanism-of-action, genetic vulnerabilities, and resistance mechanisms, all of which
Gang Wang, Michal Zimmermann, Keith S. Mascall, W. F. Lenoir, J. Moffat, S. Angers, D. Durocher, Traver Hart   +7 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Synthetic lethality guiding selection of drug combinations in ovarian cancer.

PLoS ONE, 2019
BACKGROUND:Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality.
Andreas Heinzel, Maximilian Marhold, Paul Mayer, Michael Schwarz, Erwin Tomasich, Arno Lukas, Michael Krainer, Paul Perco   +7 more
doaj   +1 more source

Carboplatin-induced hematotoxicity among patients with non-small cell lung cancer: Analysis on clinical adverse events and drug-gene interactions

OncoTarget, 2016
In order to clarify the risk of hematotoxicity of carboplatin, we inspected 19901 case reports of non-small cell lung cancer patients that were submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015.
Yiju Cheng, Ran Wu, M. Cheng, Juan Du, Xiwei Hu, Lei Yu, Xue-ke Zhao, Yu-mei Yao, Qizhong Long, Lili Zhu, Juan-juan Zhu, Ni-wen Huang, Hua-juan Liu, Ya-xin Hu, Fang Wan   +14 more
semanticscholar   +1 more source