Results 141 to 150 of about 7,299,728 (249)
Drug Sensitivity Prediction Using Machine Learning on Integrated COSMIC, DGIdb, and GDSC Data
IEEE AccessAnalyzing the relationship between drug efficacy and sensitivity to mutational profiles is necessary for the effective treatment of complex diseases such as cancer. Particularly, cancerous tissues undergo constant change as a result of ongoing mutations,
Berfu Mergen +4 more
doaj +1 more source
Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services. [PDF]
Clin Transl Sci, 2023 Pasternak AL +9 more
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Drug-drug interactions : from knowledge base to clinical impact
, 2014 Drug usage has increased steadily, and the more drugs used, the higher the risk for adverse effects or loss of effect due to drug-drug interactions. For drug prescribers it is difficult to know what drugs a patient is taking and whether they interact ...
Marine Andersson (18690100)
core +1 more source
Türk Biyokimya DergisiUnderstanding drug resistance in cancer is of importance in treatment. Cancer stem cells are main factor for drug resistance. Therefore, the possible gene/gene interactions/proteins were explored in our study using a cancer stem cell-enriched population (
Dere Egemen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Gene-gene interactions modulating the tacrolimus bioavailability.
, 2018 ANN simulations depicting gene-gene interactions in modulating tacrolimus bioavailability. (A) CYP3A5*3 -ABCB1 1236 C>T; (B) CYP3A5-ABCB1 2677 G>T/A; (C) CYP3A5-ABCB1 3435 C>T.
Kalluri Thishya (5066261) +4 more
core +1 more source
Role of Drug-Gene Interactions and Pharmacogenetics in Simvastatin-Associated Pulmonary Toxicity. [PDF]
Drug Saf, 2021 Jessurun NT +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Pharmacist assessment of drug-gene interactions and drug-induced phenoconversion in major depressive disorder: a case report. [PDF]
BMC Psychiatry, 2022 Del Toro-Pagán NM +5 more
europepmc +1 more source