Results 121 to 130 of about 8,468,954 (280)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Training toolkit on drug policy advocacy.

, 2013
This training toolkit has been developed by the International Drug Policy Consortium (IDPC) and the Eurasian Harm Reduction Network (EHRN) to build the capacity of civil society organisations for engaging with, and influencing, drug policy making ...

core  

Perspectives on drugs: Drug consumption rooms: an overview of provision and evidence. [PDF]

, 2016
Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades.

core  

Additional file 11 of Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study

, 2020
Additional file 11. Sensitivity analysis after substitution of dichotomous multimorbidity (≥2 comorbidities) with number of comorbidities.
Turner, R. M., de Koning, E. M., Fontana, V., Thompson, A., Pirmohamed, M.   +4 more
openaire   +1 more source

Identification of drug responsive enhancers by predicting chromatin accessibility change from perturbed gene expression profiles

npj Systems Biology and Applications
Individual may response to drug treatment differently due to their genetic variants located in enhancers. These variants can alter transcription factor’s (TF) binding strength, affect enhancer’s chromatin activity or interaction, and eventually change ...
Yongcui Wang, Yong Wang
doaj   +1 more source

Identifying therapeutic targets for allergic asthma through atopic dermatitis–associated genetic mechanisms

Journal of Allergy and Clinical Immunology: Global
Background: Allergic asthma (AA) is a chronic inflammatory disease with limited effective treatments, often co-occurring with atopic dermatitis (AD). Epidemiologic studies have shown a strong association between AD and AA, but their causal relationship ...
Yuping Pu, MSc, Jundong Liu, PhD, Adam N. Bennett, PhD, Kei Hang Katie Chan, PhD   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Taking stock: A decade of drug policy - A civil society shadow report. [PDF]

, 2018
Taking stock: A decade of drug policy’ evaluates the impacts of drug policies implemented across the world over the past decade, using data from the United Nations (UN), complemented with peer-reviewed academic research and grey literature reports from ...

core  

Phenoconversion: Drug-Drug-Gene Interactions [PDF]

, 2019
Based on the extensive, poor, intermediate and ultrarapid phenotypes of patients, inferences may be made relative to drug metabolism, ultimately leading to changes in therapeutic drug choice or dosing.
Kulp, Molly, Kisor, David F., Marlowe, Brooke, Roberson, Taylor, Limberg, Emily   +4 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source