Results 91 to 100 of about 6,006,054 (377)
The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations [PDF]
, 2005 This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most ...
García-Alonso, M. D. C. +1 more
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Predicting drug–drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge [PDF]
, 2017 Additional file 1. Table S1. Average structural similarity scores for the DDI/non–DDI pairs in the network of each De. Table S2-1. Top 10 predicted drugs with DDIs for warfarin. Table S2-2. Top 10 predicted drugs with DDIs for simvastatin. Table S3. Four-
Ming Hao +4 more
core +2 more sources
Journal of Research in Pharmacy Practice, 2016 Objective: Drug–drug interactions (DDIs) can cause failure in treatment and adverse events. DDIs screening software is an important tool to aid clinicians in the detection and management of DDIs.
Raziyeh Kheshti +2 more
semanticscholar +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Professional Medical Journal, 2014 Pharmacokinetic drug-drug interactions occur when the absorption, metabolism, distribution, or elimination of one drug is altered by coadministration of another. Compared with many antimicrobial drugs, the fluoroquinolones cause relatively few pharmacokinetic drug-drug interactions.
Roula Qaqish, Ronald E. Polk
openaire +3 more sources
Benchmarking network propagation methods for disease gene identification [PDF]
, 2019 In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information.
Barrett, Steven J. +5 more
core +2 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Frontiers in Pharmacology, 2019 Introduction: Drug interactions could account for 1% of hospitalizations in the general population and 2–5% of hospital admissions in the elderly. However, few data are available on the drugs concerned and the potential severity of the interactions ...
L. Létinier +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Identifikasi Drug Related Problems (DRPs) Potensial Pada Pasien Gagal Jantung Kongestif di Instalasi Rawat Inap RSU PKU Muhammadiyah Delanggu Tahun 2016 [PDF]
, 2018 Congestive heart failure is characterized by a reduced ability of the heart pump due to changes in the structure and function of the heart. DRPs increase the risk of mortality and morbidity in patients with congestive heart failure.
, Puji Asmini, M.Sc., Apt +1 more
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