Results 111 to 120 of about 7,761,818 (273)

Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data

BMC Bioinformatics, 2019
Background Although in silico drug discovery is necessary for drug development, two major strategies, a structure-based and ligand-based approach, have not been completely successful.
Y-h. Taguchi
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Systematic discovery of drug interaction mechanisms

Molecular Systems Biology, 2015
Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology.
Guillaume Chevereau, Tobias Bollenbach
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparison of YouScript^® recommendation severity of drug-drug, drug-gene, and drug-drug-gene interaction between the Home Health Trial and another published study population [16].

, 2017
Comparison of YouScript® recommendation severity of drug-drug, drug-gene, and drug-drug-gene interaction between the Home Health Trial and another published study population [16].
Moni B. Neradilek (665948), Lindsay S. Elliott (3713125), John C. Henderson (3713134), Nicolas A. Moyer (3713131), Kristine C. Ashcraft (3713128), Ranjit K. Thirumaran (379268)   +5 more
core   +1 more source

"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

The SafePolyMed Medication Management Center

Current Directions in Biomedical Engineering
Polypharmacy is a major risk factor for adverse drug events (ADEs), particularly when drug-drug and drug- gene interactions are insufficiently considered in routine care.
Gepp Sabine C., Schera Fatima, Marok Fatima, Selzer Dominik, Rüdesheim Simeon M., Just Katja S., Mosch Romy, Swen Jesse J., Lehr Thorsten, Kiefer Stephan   +9 more
doaj   +1 more source

Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain

Journal of Oral Biology and Craniofacial Research
The P2X7 receptor, a member of the P2X receptor family, plays a crucial role in various physiological processes, particularly pain perception. Its expression across immune, neuronal, and glial cells facilitates the release of pro-inflammatory molecules ...
Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Seyed Ali Mosaddad, Artak Heboyan   +3 more
doaj   +1 more source

Global Transcriptomic Analysis of the Interactions between Phage φAbp1 and Extensively Drug-Resistant Acinetobacter baumannii

mSystems, 2019
Acinetobacter baumannii is a growing threat, although lytic bacteriophages have been shown to effectively kill A. baumannii. However, the interaction between the host and the phage has not been fully studied.
Zichen Yang, Supeng Yin, Gang Li, Jing Wang, Guangtao Huang, Bei Jiang, Bo You, Yali Gong, Cheng Zhang, Xiaoqiang Luo, Yizhi Peng, Xia Zhao   +11 more
doaj   +1 more source