Drug-gene interactions - Open Access .click

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Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

2015
The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use of clinical decision support has the potential to prevent adverse effects from those drugs metabolized by this enzyme. Our initial findings after implementation of clinical decision support alerts integrated in the electronic health records suggest ...
Pedro J. Caraballo +16 more
openaire +3 more sources

CYP450 Genotyping and Cumulative Drug–Gene Interactions: An Update for Precision Medicine

Personalized Medicine, 2015
Approximately US$3.5 billion is spent annually as a result of adverse drug events (ADEs) [1], responsible for approximately a third of rehospitalizations and resulting in more than 700,000 annual emergency department visits by Medicare patients [2]. A substantial opportunity exists to reduce these iatrogenic events by taking a comprehensive and, when ...
Ranjit K, Thirumaran, Jarrod W, Heck, Brian T, Hocum +2 more
openaire +2 more sources

Graph Attention Fusion With Kolmogorov-Arnold Network for Drug-Gene Interaction Prediction

IEEE Journal of Biomedical and Health Informatics
Deep learning-based computational methods have emerged as powerful tools for predicting novel drug-gene interactions. It is essential to parse the joint influence of diverse attention focuses in large complex datasets in the model's decision-making process.
Xinguo Lu +5 more
openaire +2 more sources

Prediction of Drug-Gene Interaction by Using Biomedical Subgraph Patterns