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Mechanisms of Drug-Induced Liver Disease
Clinics in Liver Disease, 2007Drug-induced liver injury depends initially on development of hepatocyte stress and cell death, which can be induced directly by parent drugs or by toxic metabolites. Hepatocyte stress can lead to activation of built-in death programs for apoptosis or necrosis. Subsequently, the innate immune system's participation is recruited.
Basuki K, Gunawan, Neil, Kaplowitz
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Management of drug-induced liver disease
Current Gastroenterology Reports, 2001The treatment and prevention of drug-induced liver injury starts with the recognition of hepatotoxicity at the earliest possible time so that the suspected drug can be discontinued expeditiously. Both liver enzyme monitoring and vigilance for signs of hypersensitivity involving the liver are useful strategies for many agents known to cause ...
G, Marino, H J, Zimmerman, J H, Lewis
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MECHANISMS OF DRUG-INDUCED LIVER DISEASE
Gastroenterology Clinics of North America, 1995The liver is the main metabolizing organ in the body for drugs and toxins. The liver is therefore exposed to relatively high levels of electrophilic metabolites and free radicals that may induce toxicity. Furthermore, the liver performs many vital functions that may be disrupted by toxic metabolites.
L D, DeLeve, N, Kaplowitz
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Clinics in Liver Disease, 2012
Drug-induced liver injury (DILI), also known as hepatotoxicity, refers to liver injury caused by drugs or other chemical agents, and represents a special type of adverse drug reaction. It has been estimated that more than 600 drugs and chemicals have been associated with significant liver injury.
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Drug-induced liver injury (DILI), also known as hepatotoxicity, refers to liver injury caused by drugs or other chemical agents, and represents a special type of adverse drug reaction. It has been estimated that more than 600 drugs and chemicals have been associated with significant liver injury.
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Drug-induced liver disease 2004
Current Opinion in Gastroenterology, 2005To summarize the salient reviews, studies and case reports and series that dealt with clinical, pathological, methodological, and epidemiological descriptions of drug-induced liver disease in the calendar year 2004.While no new causes of drug-induced liver injury were reported for 2004, several new reports of previously recognized hepatotoxins ...
Susan K, Lazerow +2 more
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Journal of Hepatology, 2000
Drug-induced liver injuries make up a persisting and challenging problem for physicians, health agencies and pharmaceutical firms. The clinical expression is polymorphous, acute hepatitis being predominant. The diagnosis is frequently difficult because of the absence of specific signs in most cases and mainly relies on the exclusion of other causes ...
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Drug-induced liver injuries make up a persisting and challenging problem for physicians, health agencies and pharmaceutical firms. The clinical expression is polymorphous, acute hepatitis being predominant. The diagnosis is frequently difficult because of the absence of specific signs in most cases and mainly relies on the exclusion of other causes ...
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Drug-induced cholestatic liver diseases
HepatologyCholestatic DILI is an important and frequently challenging differential diagnosis in patients presenting with elevated liver tests with predominant elevation in alkaline phosphatase. A number of competing etiologies need to be ruled out, such as hepatobiliary malignancy, choledocholithiasis, cholestatic forms of viral hepatitis, cholestasis of sepsis,
Einar S. Bjornsson +1 more
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2018
Drugs are an important and common cause of hepatic injury. This is unsurprising, as the liver is a major site for drug clearance, biotransformation, and excretion. A careful history of drugs taken (prescribed, over the counter, herbal, or illicit) is vital when assessing anyone with abnormal liver function tests. Although toxic or idiosyncratic adverse
Satish Keshav, Palak Trivedi
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Drugs are an important and common cause of hepatic injury. This is unsurprising, as the liver is a major site for drug clearance, biotransformation, and excretion. A careful history of drugs taken (prescribed, over the counter, herbal, or illicit) is vital when assessing anyone with abnormal liver function tests. Although toxic or idiosyncratic adverse
Satish Keshav, Palak Trivedi
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2002
Drug-Induced Liver Disorders: Introduction and Overview Neil Kaplowitz The Role of Cytochrome P450s in Drug-Induced Liver Disease Paul B. Watkins Oxidative Stress, Antioxidant Defense, and Liver Injury Hartmut Jaeschke Hepatotoxicity Due to Mitochondrial Injury Dominique Pessayre, Abdellah Mansour, Bernard Fromenty, and Alain Berson Mechanisms of Cell ...
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Drug-Induced Liver Disorders: Introduction and Overview Neil Kaplowitz The Role of Cytochrome P450s in Drug-Induced Liver Disease Paul B. Watkins Oxidative Stress, Antioxidant Defense, and Liver Injury Hartmut Jaeschke Hepatotoxicity Due to Mitochondrial Injury Dominique Pessayre, Abdellah Mansour, Bernard Fromenty, and Alain Berson Mechanisms of Cell ...
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