Results 31 to 40 of about 640,319 (303)

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure [PDF]

, 2015
Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
A O'Riordan, A Turchinovich, AB Imaeda, AM Larson, AM Reddy, B Ekser, Carolina Palacios Jimenez, CD Williams, CL Andersen, D Mladinov, Diego Calvisi, DJ Antoine, E Cholongitas, F Martino, Fausto Andreola, G Szabo, Hatim Alibhai, HT Zhu, J Hellemans, J Vandesompele, JG O'Grady, JK Moore, K John, K Purins, K Wang, Karla C. L. Lee, KC Lee, Lewis PJ Starkey, Luisa A. Baker, M Karali, M Lagos-Quintana, M Weiland, ML Bajt, MR McGill, MW Pfaffl, N Silver, Nathan A. Davies, O Timoneda, O Timoneda, OF Laterza, P Gilje, P Landgraf, Pamela J. Leckie, PS Mitchell, Q Ge, R Bellomo, Rajeshwar P. Mookerjee, Rajiv Jalan, RL Mehta, RT Stravitz, S Bala, T Kawai, W Bernal, WE Hoffman, WM Lee, X Chen, Y Sun, Y Wang, Y Zhang, Yu-Mei Chang, YW Kong   +60 more
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Drug-induced liver injuries (part I)

Трансплантология (Москва), 2018
The paper describes current ideas on the mechanisms, classification, diagnosis, and treatment of drug-induced liver injuries (DILI). The latter masks all known acute and chronic liver diseases.
S. F. Galimova
doaj   +1 more source

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A, Davidson, Nicholas O, Dennis, Edward A, Hu, Ronglin, Karin, Gabriel, Kisseleva, Tatiana, Koyama, Yukinori, Liang, Shuang, Ma, Hsiao-Yen, Quehenberger, Oswald, Sun, Mengxi, Xu, Jun   +11 more
core   +1 more source

Drug-induced liver disease

Current Opinion in Gastroenterology, 1990
The incidence of drug-induced liver disease appears to be increasing, reflecting the increasing number of new agents that have been introduced into clinical use over the past several decades. Among the topics covered, the author discusses incidence, diagnosis, risk factors, clinical presentations, hepatitis, and vascular injury. The author also reviews
openaire   +3 more sources

Role and Mechanisms of Mitophagy in Liver Diseases

Cells, 2020
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating ...
Xiaowen Ma, Tara McKeen, Jianhua Zhang, Wen-Xing Ding   +3 more
doaj   +1 more source

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease [PDF]

, 2016
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness ...
Bell, Catherine C, Dankers, Anita CA, Ellis, Ewa, Fredriksson Puigvert, Lisa, Goldring, Christopher EP, Hendriks, Delilah FG, Ingelman-Sundberg, Magnus, Jacobs, Frank, Jenkins, Rosalind E, Kitteringham, Neil R, Lauschke, Volker M, Mkrtchian, Souren, Moro, Sabrina ML, Nordling, Åsa, Park, B Kevin, Renblom, Anna, Sison-Young, Rowena L, Snoeys, Jan, Walsh, Joanne   +18 more
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Clinical Characteristics of Liver Injury Induced by Atorvastatin [PDF]

Zhongguo quanke yixue
Background Drug-induced liver injury is one of the most common adverse drug reactions, and atorvastatin is one of the widely used statin lipid-lowering drugs in clinical practice, which is susceptible to hepatic injury.
JIANG Linshuang, CHEN Maowei
doaj   +1 more source

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites, 2020
Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with
Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, Jamal Bouitbir, Alex Odermatt   +4 more
doaj   +1 more source

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease ModelingSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Several liver diseases (eg, hepatitis B/C viruses, alcoholic/nonalcoholic fatty liver, malaria, monogenic diseases, and drug-induced liver injury) significantly impact global mortality and morbidity.
Yang Yuan, Kristen Cotton, Dinithi Samarasekera, Salman R. Khetani   +3 more
doaj   +1 more source

Orthotopic liver transplantation for fulminant and subacute hepatic failure [PDF]

, 1988
Fulminant and subacute hepatitis are conditions characterized by rapid liver failure, which can lead to death in 80 to more than 95% of the cases with medical supportive care only.
Iwatsuki, S, Starzl, TE, Stieber, AC
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